---
title: "Vaccinex will present data at AACR showing pepinemab's unique mechanism in enhancing immunotherapy, correlating with  clinical benefit in HNSCC and melanoma studies."
type: "News"
locale: "en"
url: "https://longbridge.com/en/news/236802919.md"
description: "A distinct mechanism of action for pepinemab has been identified, resulting in the generation of ample and fully developed tertiary lymphoid structures (TLS). This has been associated with long-lasting clinical improvements in patients with head and neck squamous cell carcinoma (HNSCC) as well as in a neoadjuvant trial in melanoma. The correlation between the presence of mature TLS and sustained therapeutic effects has been observed in these studies."
datetime: "2025-04-21T13:07:16.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/236802919.md)
  - [en](https://longbridge.com/en/news/236802919.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/236802919.md)
generator: "portal-rs"
---

# Vaccinex will present data at AACR showing pepinemab's unique mechanism in enhancing immunotherapy, correlating with  clinical benefit in HNSCC and melanoma studies.

A distinct mechanism of action for pepinemab has been identified, resulting in the generation of ample and fully developed tertiary lymphoid structures (TLS). This has been associated with long-lasting clinical improvements in patients with head and neck squamous cell carcinoma (HNSCC) as well as in a neoadjuvant trial in melanoma. The correlation between the presence of mature TLS and sustained therapeutic effects has been observed in these studies.

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---
> **Disclaimer: This article is for reference only and does not constitute any investment advice.**