---
title: "20:30 ET\n\t\t\t\n\t\t\t\n\t\t\t\tAntengene Presents Four Posters at AACR 2025 Highlighting Focuses on AnTenGagerTM TCEs and Synthetic Lethality"
description: "Antengene Corporation Limited presented four posters at the AACR 2025, showcasing its innovative biopharmaceutical programs. Key highlights include ATG-201, a CD19 x CD3 T cell engager aimed at treati"
type: "news"
locale: "en"
url: "https://longbridge.com/en/news/237633328.md"
published_at: "2025-04-26T00:31:14.000Z"
---

# 20:30 ET
			
			
				Antengene Presents Four Posters at AACR 2025 Highlighting Focuses on AnTenGagerTM TCEs and Synthetic Lethality

> Antengene Corporation Limited presented four posters at the AACR 2025, showcasing its innovative biopharmaceutical programs. Key highlights include ATG-201, a CD19 x CD3 T cell engager aimed at treating B cell malignancies, and ATG-042, a selective PRMT5 inhibitor for MTAPnull cancers. Both programs are set to enter clinical development in the latter half of 2025. The presentations emphasize Antengene's commitment to developing first-in-class therapies for hematologic malignancies and solid tumors.

, /PRNewswire/ -- Antengene Corporation Limited ("**Antengene**", SEHK: 6996.HK), a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for hematologic malignancies and solid tumors, today announced that **it has released results from four preclinical studies in poster presentations at the 2025 American Association for Cancer Research Annual Meeting (AACR 2025)**. **These four posters feature Antengene's four highly differentiated and high-potential programs, including ATG-201 (CD19 x CD3 TCE) and ATG-042 (MTAPnull\-selective PRMT5 Inhibitor), which are poised to enter clinical development in the second half of 2025; ATG-110 (LY6G6D x CD3 TCE), which was developed on the AnTenGagerTM TCE 2.0 platform for the treatment of microsatellite stable colorectal cancer; and a companion diagnostic antibody developed to assess CD24 expression and guide clinical studies of CD24-targeted therapies.**

**Details of the Poster Presentations:  
****ATG-201 (CD19 x CD3 T cell engager)  
****Title:** ATG-201, a novel T-cell engager (TCE) effectively depletes B cells with reduced risk of CRS for the treatment of B cell malignancies and B cell related autoimmune diseases  
**Abstract Number:** 7326  
**Session Category:** Immunology  
**Session Title:** T Cell Engagers and Novel Antibody-Based Therapies  
**Date:** April 30, 2025  
**Time:** 9:00 AM - 12:00 PM (Central Time)  
10:00 PM, April 30, 2025 - 1:00 AM, May 1, 2025 (Beijing Time)  
**Location:** Poster Section 40  
• **Introduction:** By depleting autoreactive B cells, CD19-targeted CAR-T have shown early yet promising efficacy in treating patients with B cell-driven autoimmune diseases. However, the clinical application of TCE continues to be greatly hindered by the unfavorable pharmacokinetics and toxicity associated with cytokine release syndrome. To overcome these limitations, Antengene developed ATG-201, a "2+1" CD19 x CD3 TCE, which was evaluated in a series of *in vitro* studies for binding affinity, T cell dependent cytotoxicity (TDCC) cytokine release, and drug developability. The *in vivo* anti-lymphoma efficacy and pharmacodynamic effect were evaluated in Raji xenograft model. The tissue resident B cell depletion was assessed in CD34+ hematopoietic stem cells humanized mice. Pharmacokinetic parameters of ATG-201 were evaluated in normal Balb/c mice.  
• **Results:** ATG-201 demonstrated high affinity binding to CD19, limited T cell binding before CD19 crosslinking, highly potent CD19-dependent T cell cytotoxicity against CD19+ B cells, as well as enhanced naïve B cell depletion with reduced cytokine release compared to clinical benchmarks. In lymphoma models, the study observed potent *in vivo* efficacy with reduced cytokine release. In CD34+ hematopoietic stem cells humanized mice, ATG-201 was able to induce complete B cell depletion with reduced cytokine release. ATG-201 has a mAb-like pharmacokinetic profile in wild type mice and good drug developability. Moreover, surrogate CD19 x CD3 AnTenGager TCE displayed potent efficacy in MRL/lpr spontaneous systemic lupus erythematosus (SLE) mouse models and MOG-Induced EAE models.  
• **Conclusions:** ATG-201 demonstrated CD19-dependent CD3 binding and activation, inducing effective B cell depletion *in vitro* and *in vivo* with low cytokine release, which provides potential for the treatment of B cell malignancies and B cell related autoimmune diseases. ATG-201 is poised to enter clinical development in the second half of 2025.

**ATG-042 (MTAPnull\-selective PRMT5 Inhibitor)  
****Title:** Preclinical characterization of ATG-042, a novel MTAPnull\-selective PRMT5 inhibitor  
**Abstract Number:** 4230  
**Session Category:** Experimental and Molecular Therapeutics  
**Session Title:** HDAC and Methyltransferase Inhibitors  
**Date:** April 29, 2025  
**Time:** 9:00 AM - 12:00 PM (Central Time)  
10:00 PM, April 29, 2025 - 1:00 AM, April 30, 2025 (Beijing Time)  
**Location:** Poster Section 16  
**• Introduction:** Targeting the PRMT5-MTA complex has become a promising strategy for treating MTAPnull cancer in a synthetically lethal manner, avoiding on-target-off-tumor hematological toxicity when using first-generation, non-selective PRMT5 inhibitors. Herein, Antengene developed ATG-042, a novel MTAPnull\-selective PRMT5 small molecule inhibitor with good brain penetration. In this study, the *in vitro* activity and MTAP selectivity of ATG-042 were profiled using HCT116 MTAP wild type (wt) cells, HCT116 MTAP knock out (ko) cells and multiple endogenous MTAPnull cell lines. The *in vivo* efficacy was tested in cell derived xenograft (CDX) mouse models with HCT116 MTAP wt cells, HCT116 MTAP ko cells, LU99 cells (MTAPnull) and U87MG-luc (MTAPnull). The pharmacokinetic and toxicological properties were assessed with corresponding assay methods.  
**• Results:** ATG-042 showed excellent anti-proliferative activities on multiple endogenous MTAPnull cell lines with IC50 values between 10nM and 100nM. ATG-042 demonstrated high permeability, good metabolic stability, and low risk of drug-drug interaction. *In vivo* PK study shows that ATG-042 is well absorbed, with a dose-dependent increase in plasma distribution and high oral bioavailability in mice, SD rats and beagle dogs. Furthermore, ATG-042 is brain-penetrable (B/P ratio=51% in mice; KPuubrain\=0.73 in rats). ATG-042 showed robust *in vivo* efficacy in both subcutaneous CDX models (HCT116 -MTAP ko, LU99) and orthotopic CDX model (U87MG-luc) as a single agent. In addition, ATG-042 also exhibited potential synergy in combination with other drugs for antitumor therapy.  
**• Conclusions:** ATG-042 is an oral MTAPnull\-selective PRMT5 inhibitor with potent efficacy against MTAPnull tumor. It also demonstrated good tolerability and brain penetrability. ATG-042 is poised to enter clinical development in the second half of 2025.

**ATG-110 (LY6G6D x CD3 T** **cell engager)  
****Title:** ATG-110, a novel "2+1" LY6G6D-targeted T-cell Engager (TCE) with high potency for the treatment of MSS colorectal cancer  
**Abstract Number:** 3509  
**Session Category:** Immunology  
**Session Title:** T Cell Engagers  
**Date:** April 28, 2025  
**Time:** 2:00 PM - 5:00 PM (Central Time)  
3:00 AM - 6:00 AM, April 29, 2025 (Beijing Time)  
**Location:** Poster Section 38  
• **Introduction:** Colorectal cancer (CRC) is one of the most common cancers worldwide and requires more effective and safer therapies to improve the poor survival outcome, particularly in patients with microsatellite stable (MSS) colorectal cancer, who exhibit primary resistance to immune checkpoint inhibitors and lack effective treatment options. T cell engagers have shown encouraging efficacy in treating hematological malignancies, while exhibiting suboptimal clinical efficacies in solid tumors. The risk of cytokine release syndrome (CRS) remains as a significant challenge clinically. ATG-110 is a novel "2+1" LY6G6D x CD3 TCE developed by Antengene. In this study, ATG-110 was evaluated in a series of preclinical *in vitro* studies for binding affinity, T cell activation and cytokine release, T cell dependent cytotoxicity (TDCC), and drug developability. The *in vivo* anti-tumor efficacy was evaluated in PBMC-humanized immunodeficient NDG mice engrafted with LY6G6Dmedium\-expression HT55 or LY6G6Dvery low\-expression SW480 MSS CRC cells.  
• **Results:** ATG-110 binds to LY6G6D-positive cell lines, including LY6G6D-overexpression 293T and HT55 with the nanomolar grade EC50. The CD3 binding site of ATG-110 is concealed by the LY6G6D Fab arm before binding to LY6G6D, due to the steric hindrance. Therefore, ATG-110 demonstrated limited binding capability to CD3+ cells before LY6G6D crosslinking. It activates T cells and induces cytokine release only in the presence of LY6G6D+ cells. *In vitro*, ATG-110 resulted in potent T cell dependent cytotoxicity with single-digit pM IC50 values on HT55 cells. ATG-110 also showed highly potent *in vitro* efficacy against LY6G6Dlow\-expression cells. ATG-110 exhibited a low risk of inducing cytokine release syndrome. ATG-110 demonstrated potent anti-tumor activity in PBMC-humanized HT55 xenograft model. Furthermore, ATG-110 also demonstrated good drug developability.  
• **Conclusions:** ATG-110 demonstrated LY6G6D-dependent CD3 binding and activation with low risk of CRS. It showed powerful *in vitro* and *in vivo* anti-tumor efficacy against colorectal cancer, which warrants further clinical evaluation.

**ATG-1144 (CD24 CDx Antibody)  
****Title:** Development of a diagnostic antibody for CD24 targeted therapy  
**Abstract Number:** 671  
**Session Category:** Clinical Research  
**Session Title:** Diagnostic Biomarkers 2  
**Date:** April 27, 2025  
**Time:** 2:00 PM - 5:00 PM (Central Time)  
3:00 AM - 6:00 AM, April 28, 2025 (Beijing Time)  
**Location:** Poster Section 29  
• **Introduction:** CD24 has emerged as a promising therapeutic target for anti-cancer treatment. Several clinical trials are being conducted to evaluate the safety and efficacy of CD24-targeted therapies. Here, Antengene developed and characterized an anti-CD24 diagnostic antibody to enhance the screening and selection of patients based on CD24 expression. In this study, the authors described the discovery of the diagnostic antibody, and the evaluation of accuracy, sensitivity (selectivity), specificity, and assay precision of the antibody.  
• **Results:** Monoclonal antibody clone ATG-1144 binds to the hCD24 core peptide in ELISA with an EC50 of 0.06 nM. Distinct membrane staining on human normal esophageal tissue FFPE specimens can also be observed with IHC staining using ATG-1144. For accuracy assessment, six CDX and twenty human specimens, comprising both positive and negative specimens (including solid tumors and B-cell non-Hodgkin lymphomas), were validated. Samples exhibiting high, medium, and low CD24 expression levels were evaluated for sensitivity and specificity, and the interpreted results aligned with the reference outcomes. FFPE tissues from three distinct patients were evaluated for assay precision assessment. The TMA IHC staining result revealed that 50-80% of patients with lung, breast, bladder, ovarian, or liver cancer have CD24 expression on tumor cell surface with low expression in the para-cancerous normal tissue.  
• **Conclusions:** ATG-1144 specifically binds to human CD24 with high sensitivity as demonstrated by IHC staining. The development and validation of the method have been finalized using Leica Bond III platforms. These data suggest a potential diagnostic use of ATG-1144 for identifying CD24+ patients.

**About Antengene  
**Antengene Corporation Limited (**"Antengene"**, SEHK: 6996.HK) is a leading commercial-stage R&D-driven global biopharmaceutical company focused on the discovery, development, manufacturing and commercialization of innovative first-in-class/best-in-class therapeutics for the treatment of hematologic malignancies and solid tumors, in realizing its vision of **"Treating Patients Beyond Borders"**.  
Antengene has built a pipeline of 9 oncology assets at various stages going from clinical to commercial, including 6 with global rights, and 3 with rights for the APAC region. To date, Antengene has obtained 31 investigational new drug (IND) approvals in the U.S. and Asia, and submitted new drug applications (NDAs) in 11 Asia Pacific markets, with the NDA for XPOVIO® (selinexor) already approved in Mainland of China, Taiwan China, Hong Kong China, Macau China, South Korea, Singapore, Malaysia, Thailand, Indonesia and Australia.

**Forward-looking statements  
**The forward-looking statements made in this article relate only to the events or information as of the date on which the statements are made in this article. Except as required by law, we undertake no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise, after the date on which the statements are made or to reflect the occurrence of unanticipated events. You should read this article completely and with the understanding that our actual future results or performance may be materially different from what we expect. In this article, statements of, or references to, our intentions or those of any of our Directors or our Company are made as of the date of this article. Any of these intentions may alter in light of future development. For a further discussion of these and other factors that could cause future results to differ materially from any forward-looking statement, please see the other risks and uncertainties described in the Company's Annual Report for the year ended December 31, 2024, and the documents subsequently submitted to the Hong Kong Stock Exchange.

For more information, please contact:

Investor Contacts:  
Donald Lung  
E-mail: \[email protected\]  
Mobile: +86 18420672158

PR Contacts:  
Peter Qian  
E-mail: \[email protected\]  
Mobile: +86 13062747000

SOURCE Antengene Corporation Limited

### Related Stocks

- [06996.HK - ANTENGENE-B](https://longbridge.com/en/quote/06996.HK.md)

## Related News & Research

| Title | Description | URL |
|-------|-------------|-----|
| 06:16 ETSpace Prize Foundation 启动教育公平计划，惠及数百名布朗斯维尔学生及家庭 | Space Prize Foundation 今日宣布启动一项全新教育公平计划，旨在为德克萨斯州布朗斯维尔地区教育资源匮乏的学生和家庭，拓展参与太空与 STEM 实践学习的机会。该项目将为 500 余名二年级学生及 42 个家庭提供沉浸式博 | [Link](https://longbridge.com/en/news/276436056.md) |
| 全球财政刺激 “雷声大雨点小”？瑞银预计仅为 2026 年 GDP 增长贡献 8 个基点 | 瑞银研究指出，2026 年全球财政刺激实际影响接近中性，对 GDP 增长贡献仅约 8 个基点。尽管美、日、德等国法案热度高，但由于执行速度缓慢及新兴市场财政整固，实际力度远低于历史水平。全球经济仍需寻找内生动力，而非寄希望于政策红利。 | [Link](https://longbridge.com/en/news/276317126.md) |
| 贝森特和沃什的 “导师”，德鲁肯米勒 Q4“精准” 开仓金融股 ETF、标普等权重 ETF 和巴西 ETF | 科技股方面，德鲁肯米勒 Q4 清仓了 Meta，加仓了谷歌与 Sea。德鲁肯米勒与贝森特、沃什的 “师徒” 关系让市场推测，“德鲁肯米勒经济学”——即反赤字、反通胀、反关税——可能通过贝森特和沃什渗透至政策制定中。 | [Link](https://longbridge.com/en/news/276214511.md) |
| 达利欧家办重仓黄金！彻底退出桥水后首曝美股持仓，规模升至 5 亿美元 | 达利欧家族办公室自疫情以来首次披露美国股票投资情况。截至去年年底，其在美股市场持仓约 5.03 亿美元，较 2021 年初增长约三分之一。其中超过四分之三资金配置在黄金 ETF，其余分散布局美债及标普 500 指数等资产。分析称，这一举动显 | [Link](https://longbridge.com/en/news/276472669.md) |
| 马塞里奇房产｜10-K：2025 财年营收 10.14 亿美元 |  | [Link](https://longbridge.com/en/news/276448925.md) |

---

> **Disclaimer**: This article is for reference only and does not constitute any investment advice.
