---
title: "Promising Phase IIa Results and Favorable Safety Profile Drive Buy Rating for Skye Bioscience’s Nimacimab"
description: "Andy Hsieh has issued a Buy rating for Skye Bioscience’s nimacimab following promising Phase IIa trial results, particularly its combination with Wegovy, which showed significant weight loss. Despite "
type: "news"
locale: "en"
url: "https://longbridge.com/en/news/260075514.md"
published_at: "2025-10-06T15:55:34.000Z"
---

# Promising Phase IIa Results and Favorable Safety Profile Drive Buy Rating for Skye Bioscience’s Nimacimab

> Andy Hsieh has issued a Buy rating for Skye Bioscience’s nimacimab following promising Phase IIa trial results, particularly its combination with Wegovy, which showed significant weight loss. Despite not meeting the primary endpoint as a monotherapy, nimacimab's favorable safety profile, with no serious adverse events and low discontinuation rates, supports its tolerability. Skye's plans for higher dosing strategies and further trial results presentation enhance the positive outlook. H.C. Wainwright also initiated coverage with a Buy rating and a $20.00 price target.

Andy Hsieh has given his Buy rating due to a combination of factors, primarily focusing on the recent Phase IIa trial results for Skye Bioscience’s nimacimab. Although the monotherapy did not achieve the primary endpoint, the combination with Wegovy showed promising results with a significant increase in weight loss compared to Wegovy alone. This outcome suggests potential for further development and optimization of the treatment.  
Additionally, the safety profile of nimacimab was favorable, with no neuropsychiatric adverse events reported and minimal gastrointestinal issues when combined with Wegovy. The low discontinuation rates due to adverse events further support the drug’s tolerability. Skye Bioscience’s plan to explore higher dosing strategies and present more detailed trial results at an upcoming conference indicates a proactive approach to advancing their research, which contributes to the positive outlook reflected in the Buy rating.

According to TipRanks, Hsieh is a 4-star analyst with an average return of 10.6% and a 47.24% success rate. Hsieh covers the Healthcare sector, focusing on stocks such as Skye Bioscience, Viking Therapeutics, and Terns Pharmaceuticals.

In another report released on September 30, H.C. Wainwright also initiated coverage with a Buy rating on the stock with a $20.00 price target.

### Related Stocks

- [SKYE.US - Skye Bioscience](https://longbridge.com/en/quote/SKYE.US.md)

## Related News & Research

| Title | Description | URL |
|-------|-------------|-----|
| Skye Bioscience Launches Phase 2a Trial of Nimacimab for Obesity Treatment | Skye Bioscience Inc. has launched a Phase 2a clinical trial for nimacimab, a CB1 inhibitor antibody aimed at treating ob | [Link](https://longbridge.com/en/news/274145896.md) |
| Skye Bioscience Unveils Presentation on Nimacimab for Obesity and Metabolic Disease Treatment | Skye Bioscience Inc. has presented details on nimacimab, a CB1-inhibiting antibody aimed at treating obesity and metabol | [Link](https://longbridge.com/en/news/272309211.md) |
| WPTG Enters Into LOI To Acquire Swedish Company Servit | White Pearl Technology Group AB :WPTG, THROUGH ITS SUBSIDIARY ADLIGO AB, HAS ENTERED INTO AN LOI TO ACQUIRE THE SWEDISH  | [Link](https://longbridge.com/en/news/276099320.md) |
| EU approves higher dose of Novo's Wegovy | The European Commission has approved a higher dose of Novo Nordisk's popular weight-loss drug Wegovy, the Danish drugmak | [Link](https://longbridge.com/en/news/276134250.md) |
| Skye Bioscience Showcases New Obesity Drug Data Highlighting Add-On Benefits to GLP-1 Therapies | Skye Bioscience Inc. has presented new data on its investigational obesity treatment, nimacimab, which complements exist | [Link](https://longbridge.com/en/news/266662439.md) |

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> **Disclaimer**: This article is for reference only and does not constitute any investment advice.