---
title: "Top 5 US Stock Gainers/Losers (>100B) (10.17)"
description: "American Express(AXP) rose 7.27%, with a trading turnover 2.4 Billion USD, and a year-to-date rose 18%. Gilead Sciences(GILD) rose 4.21%, with a trading turnover 1.9 Billion USD, and a year-to-date ro"
type: "news"
locale: "en"
url: "https://longbridge.com/en/news/261689526.md"
published_at: "2025-10-17T22:00:51.000Z"
---

# Top 5 US Stock Gainers/Losers (>100B) (10.17)

> American Express(AXP) rose 7.27%, with a trading turnover 2.4 Billion USD, and a year-to-date rose 18%. Gilead Sciences(GILD) rose 4.21%, with a trading turnover 1.9 Billion USD, and a year-to-date rose 35.8%. Oracle(ORCL) fell 6.93%, with a trading turnover 11.0 Billion USD, and a year-to-date rose 76.5%. Biodexa Pharmaceuticals(BDRX) fell 6.83%, with a trading turnover 174.5 Thousand USD, and a year-to-date fell 80.8%.

NASDAQ Composite Index has rose 0.52%, with a year-to-date rose 17.4%; S&P 500 has rose 0.53%, with a year-to-date rose 13.3%; Dow Jones Industrial Average has rose 0.52%, with a year-to-date rose 8.6%.

American Express(AXP) rose 7.27%, with a trading turnover 2.4 Billion USD, and a year-to-date rose 18%.

Gilead Sciences(GILD) rose 4.21%, with a trading turnover 1.9 Billion USD, and a year-to-date rose 35.8%.

Oracle(ORCL) fell 6.93%, with a trading turnover 11.0 Billion USD, and a year-to-date rose 76.5%.

Biodexa Pharmaceuticals(BDRX) fell 6.83%, with a trading turnover 174.5 Thousand USD, and a year-to-date fell 80.8%.

### Related Stocks

- [AXP.US - American Express](https://longbridge.com/en/quote/AXP.US.md)
- [GILD.US - Gilead Sciences](https://longbridge.com/en/quote/GILD.US.md)
- [COF.US - Capital One Financial](https://longbridge.com/en/quote/COF.US.md)
- [HDB.US - HDFC Bank](https://longbridge.com/en/quote/HDB.US.md)
- [IBN.US - ICICI Bank](https://longbridge.com/en/quote/IBN.US.md)
- [ORCL.US - Oracle](https://longbridge.com/en/quote/ORCL.US.md)
- [BDRX.US - Biodexa Pharmaceuticals](https://longbridge.com/en/quote/BDRX.US.md)
- [IBKR.US - Interactive Brokers](https://longbridge.com/en/quote/IBKR.US.md)
- [ARM.US - Arm](https://longbridge.com/en/quote/ARM.US.md)
- [NVO.US - Novo Nordisk AS](https://longbridge.com/en/quote/NVO.US.md)

## Related News & Research

| Title | Description | URL |
|-------|-------------|-----|
| American Express Chief Legal Officer Laureen Seeger Reports Disposal of Common Shares | Laureen Seeger, Chief Legal Officer of American Express Company, has reported the disposal of common shares of the compa | [Link](https://longbridge.com/en/news/275509632.md) |
| Why Oracle stock popped today | The database leader is poised for a rebound. | [Link](https://longbridge.com/en/news/275380219.md) |
| American Express Extends Multiyear Partnership With NBA | American Express has extended its multiyear partnership with the NBA, which now includes the WNBA, NBA G League, USA Bas | [Link](https://longbridge.com/en/news/275471784.md) |
| Top American Express Executive Executes Major Insider Stock Move | American Express Group President Howard Grosfield sold 8,134 shares of AXP stock for $2.82 million on February 13, 2026, | [Link](https://longbridge.com/en/news/275961369.md) |
| Where will American Express stock be in 3 years? | American Express stock has tripled in five years. A recent premium card relaunch suggests the good times aren't over yet | [Link](https://longbridge.com/en/news/275208845.md) |

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> **Disclaimer**: This article is for reference only and does not constitute any investment advice.
