---
title: "Apogee Therapeutics: Strong Phase II AD Data and 2026 Readouts Underpin Buy Rating and Potential to Displace JAK-Based Regimens"
type: "News"
locale: "en"
url: "https://longbridge.com/en/news/278568437.md"
description: "TD Cowen analyst Tyler Van Buren has maintained a Buy rating on Apogee Therapeutics (APGE) stock, citing strong Phase II data for its lead asset and upcoming catalysts. He anticipates pivotal clinical readouts in 2026 that could position the company to challenge JAK-based treatments. The 16-week Phase II data showed significant EASI-75 responses, outperforming expectations. Citi also supports the stock with a Buy rating and a $95 price target."
datetime: "2026-03-10T13:45:25.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/278568437.md)
  - [en](https://longbridge.com/en/news/278568437.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/278568437.md)
---

> Supported Languages: [简体中文](https://longbridge.com/zh-CN/news/278568437.md) | [繁體中文](https://longbridge.com/zh-HK/news/278568437.md)


# Apogee Therapeutics: Strong Phase II AD Data and 2026 Readouts Underpin Buy Rating and Potential to Displace JAK-Based Regimens

TD Cowen analyst Tyler Van Buren has maintained their bullish stance on APGE stock, giving a Buy rating on March 5.

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Tyler Van Buren has given his Buy rating due to a combination of factors related to Apogee Therapeutics’ lead asset and upcoming catalysts. He views 2026 as a pivotal year, with multiple clinical readouts from the Phase II AD zumi program and the APG279 OX40L combination that could position the company to challenge or even displace current JAK-based regimens in second-line treatment.

He highlights that the 16-week Phase II data for zumi in moderate-to-severe AD patients significantly outperformed expectations, showing strong EASI-75 responses even against an unusually high placebo rate, and appearing numerically better than existing standard-of-care biologics. Van Buren also emphasizes the potential of 52-week data to confirm durable efficacy with less frequent dosing (every 3–6 months), the ability to advance both Q3M and Q6M regimens into Phase III, and the strong exposure–response relationship that supports confidence in Part B and later-stage studies, all of which underpin his favorable risk-reward view and Buy recommendation.

In another report released on March 5, Citi also maintained a Buy rating on the stock with a $95.00 price target.

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