---
title: "Pre-market hot trades in US stocks: Aprea Therapeutics pre-market down 9.53%; Serina Therapeutics pre-market up 7.22%"
type: "News"
locale: "en"
url: "https://longbridge.com/en/news/281331893.md"
description: "Aprea Therapeutics pre-market down 9.53%; Serina Therapeutics pre-market up 7.22%; Hub Cyber Security pre-market up 55.79%; Binah Capital pre-market up 50.75%; Xiaoi Robot pre-market up 41.91%"
datetime: "2026-04-01T08:47:52.000Z"
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  - [zh-CN](https://longbridge.com/zh-CN/news/281331893.md)
  - [en](https://longbridge.com/en/news/281331893.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/281331893.md)
---

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# Pre-market hot trades in US stocks: Aprea Therapeutics pre-market down 9.53%; Serina Therapeutics pre-market up 7.22%

**Pre-market Hot Trades in US Stocks**

Aprea Therapeutics is down 9.53% in pre-market trading. Based on recent key news:

1.  On March 30, Aprea Therapeutics announced that its WEE1 inhibitor APR-1051 showed positive clinical activity in the ongoing ACESOT-1051 Phase I trial, confirming partial responses. This news boosted market confidence in its R&D prospects, leading to a rise in stock price during pre-market trading.
    
2.  On March 30, the company projected that its financing would extend cash flow into the first quarter of 2028. This news indicates a solid financial position for the company, enhancing investor confidence and pushing the stock price up 8.35% in pre-market trading.
    
3.  On March 27, Aprea Therapeutics' stock closed at $0.68, down 2.43%. This decline may be related to market concerns about the company's short-term financial performance. The biotech industry has seen active R&D activities recently.
    

Serina Therapeutics is up 7.22% in pre-market trading. There has been no significant news from Serina Therapeutics recently; trading is active with clear capital flows. Considering sector and industry trends, the stock shows notable volatility, and specific reasons need further observation. no\_news

**Top Gainers in Pre-market US Stocks**

Hub Cyber Security is up 55.79% in pre-market trading. Based on recent key news:

1.  On March 31, HUB Cyber Security announced the resignation of CEO Noah Hershcoviz, with Renah Persofsky taking on more management responsibilities. This news attracted market attention, causing stock price fluctuations.
    
2.  On March 31, the company received conversion requests for approximately $1.7 million in convertible notes, triggering the issuance of 12,038,376 shares of common stock, increasing the outstanding shares to 21,082,357.
    
3.  On March 31, several company executives submitted initial stock ownership filings, indicating confidence in the company's future, which may boost investor sentiment. The market is sensitive to management changes and should be monitored.
    

Binah Capital is up 50.75% in pre-market trading. Based on recent key news:

1.  On March 31, Binah Capital released its Q4 2025 and full-year financial report, showing that the company's performance exceeded market expectations, driving a significant rise in stock price. According to SEC filings, the report indicated substantial growth in both revenue and profit, enhancing investor confidence and leading to a 50.75% increase in pre-market stock price. Source: SEC announcement
    
2.  On March 31, the market reacted positively to Binah Capital's financial report, with investors optimistic about the company's future growth prospects. Following the report's release, market analysts raised the company's ratings, further driving up the stock price. Source: BCG Stock News On March 31, after the financial report of Binah Capital was released, trading volume significantly increased, indicating strong market interest in the stock. Investors recognized the company's performance in 2025, leading to a substantial rise in stock price. Source: BCG Stock News Market reacts positively to financial report, trading volume increases.
    

Xiao i Robot pre-market rose by 41.91%. Based on recent key news:

1.  On March 31, the Supreme People's Court of China upheld the validity of Xiao i Robot's core AI patents, rejecting Apple's application for patent invalidation. This ruling is final and cannot be appealed, enhancing market confidence in Xiao i Robot's patent rights and driving a significant increase in stock price. Source: PR Newswire
    
2.  On March 27, the Supreme People's Court made a final ruling on Apple's appeal, officially rejecting Apple's request to declare Xiao i Robot's VIE-related patents invalid. This news further solidified Xiao i Robot's market position and boosted investor confidence. Source: Company Announcement
    
3.  On March 31, Xiao i Robot updated its progress on the patent infringement lawsuit against Apple. Although the validity of the patents has been confirmed, the outcome of the infringement compensation has not yet been resolved. This uncertainty may continue to affect market sentiment. Source: AIXI Stock News AI industry patent disputes impact market sentiment

### Related Stocks

- [Aprea Therapeutics, Inc. (APRE.US)](https://longbridge.com/en/quote/APRE.US.md)
- [Serina Therapeutics, Inc. (SER.US)](https://longbridge.com/en/quote/SER.US.md)

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