---
title: "Most and least shorted healthcare stocks with up to $2B market cap in May"
type: "News"
locale: "en"
url: "https://longbridge.com/en/news/285083732.md"
description: "Short sellers have increased their positions in small-cap healthcare stocks, particularly those under $2 billion market cap, leading to heightened bearish sentiment. Sensei Biotherapeutics tops the list with a short interest of 63.85%, followed by KalVista Pharmaceuticals at 38.35%. Conversely, Beyond Air and Polaryx Therapeutics have minimal short interest at 0.50%. The healthcare sector has underperformed, with the Health Care Select Sector SPDR® Fund declining 6.23% year-to-date, despite the S&P 500's 5.62% rally."
datetime: "2026-05-04T14:02:20.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/285083732.md)
  - [en](https://longbridge.com/en/news/285083732.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/285083732.md)
---

# Most and least shorted healthcare stocks with up to $2B market cap in May


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- [PLYX.US](https://longbridge.com/en/quote/PLYX.US.md)
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