--- title: "Theriva Q1 Net Loss Narrows; Plans Dosing Feasibility Study Of VCN-01 In H2,2026;Stock Down" type: "News" locale: "en" url: "https://longbridge.com/en/news/285347619.md" description: "Theriva Biologics, Inc. (TOVX) reported a narrower net loss of $2.04 million for Q1 2026, down from $4.32 million the previous year. The company has $14.4 million in cash, expected to last until Q1 2027. They plan to conduct a dosing feasibility study for their lead candidate VCN-01 in metastatic pancreatic cancer, starting in H2 2026. The stock closed at $0.38, but is down 4.26% in pre-market trading at $0.36." datetime: "2026-05-06T09:35:16.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/285347619.md) - [en](https://longbridge.com/en/news/285347619.md) - [zh-HK](https://longbridge.com/zh-HK/news/285347619.md) --- # Theriva Q1 Net Loss Narrows; Plans Dosing Feasibility Study Of VCN-01 In H2,2026;Stock Down (RTTNews) - Theriva Biologics, Inc. (TOVX), a clinical-stage company, reported financial results for the first quarter ended March 31, 2026, reflecting a narrower net loss and highlighted near-term milestones for its lead candidate VCN-01. **Company Profile** Theriva develops therapeutics for the treatment of cancer and related diseases. The Company's lead clinical-stage candidate is VCN-01 (Zabilugene almadenorepvec), an oncolytic adenovirus designed to replicate selectively and aggressively within tumour cells and degrade the tumour stroma, an important physical and immunosuppressive barrier to cancer treatment. **First Quarter Results** Net losses attributable to common shareholders narrowed to $2.04 million compared to $4.32 million in the prior year. As of March 31, 2026, cash and cash equivalents totalled $14.4 million and are expected to provide cash runway into the first quarter of 2027. **Near-Term Milestones** Theriva noted that it has reached alignment with the FDA on the Phase 3 trial design for VCN-01 (zabilugene almadenorepvec) for the treatment of metastatic pancreatic ductal adenocarcinoma (PDAC). As the firm has finalised the pivotal Phase 3 study protocol, they plan to generate feasibility data for the intended Phase 3 macrocycle dosing regimen by conducting a small study in metastatic PDAC patients who receive more frequent VCN-01 doses for a longer period. This dosing feasibility study is expected to commence at a single site in Spain in the second half of this year. In addition, VCN-01 is administered to retinoblastoma patients under a compassionate use program, which may provide dosing feasibility and tolerability data for a potential Phase 2/3 clinical trial. If a protocol is submitted and agreed upon by the FDA, the firm expects the first patient enrolled in December 2026, with a rolling Biologics License Application (BLA) submission expected in 2029. TOVZ has traded between $0.16 and $1.45 over the last year. The stock closed Tuesday's trade at $0.38, up 0.11%. In the pre-market, TOVX is down 4.26% at $0.36. For More Such Biotech Stock News, visit rttnews.com. The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc. ### Related Stocks - [TOVX.US](https://longbridge.com/en/quote/TOVX.US.md) - [ARKG.US](https://longbridge.com/en/quote/ARKG.US.md) - [PBE.US](https://longbridge.com/en/quote/PBE.US.md) - [LABU.US](https://longbridge.com/en/quote/LABU.US.md) - [BBH.US](https://longbridge.com/en/quote/BBH.US.md) - [FBT.US](https://longbridge.com/en/quote/FBT.US.md) - [IHE.US](https://longbridge.com/en/quote/IHE.US.md) - [SBIO.US](https://longbridge.com/en/quote/SBIO.US.md) - [IBBQ.US](https://longbridge.com/en/quote/IBBQ.US.md) - [IBB.US](https://longbridge.com/en/quote/IBB.US.md) - [XLV.US](https://longbridge.com/en/quote/XLV.US.md) - [VHT.US](https://longbridge.com/en/quote/VHT.US.md) - [XBI.US](https://longbridge.com/en/quote/XBI.US.md) - [BIB.US](https://longbridge.com/en/quote/BIB.US.md) - [IXJ.US](https://longbridge.com/en/quote/IXJ.US.md) - [NDAQ.US](https://longbridge.com/en/quote/NDAQ.US.md) ## Related News & Research - [Relay drug shows early promise against rare blood vessel diseases](https://longbridge.com/en/news/287094432.md) - [NeOnc Advances Glioma Programs and Strengthens Financial Position](https://longbridge.com/en/news/286826865.md) - [Eton Pharmaceuticals Adds Another 2026 Launch As It Secures U.S. Rights To IMPAVIDO](https://longbridge.com/en/news/287025596.md) - [BioMarin's drug shows significant growth gains in children in late-stage trial](https://longbridge.com/en/news/287121584.md) - [US cancer clinics scramble to get experimental Revolution Medicines pancreatic cancer drug](https://longbridge.com/en/news/286394551.md)