--- title: "" type: "News" locale: "en" url: "https://longbridge.com/en/news/285421024.md" description: "Bayer has agreed to acquire Perfuse Therapeutics for up to $2.45 billion, with $300 million upfront. Madrigal Pharmaceuticals secured a global license for ARO-PNPLA3, a siRNA therapy, for $25 million upfront and up to $975 million in milestones. Zentalis Pharmaceuticals has dosed the first patient in a Phase III trial for a WEE1 inhibitor in ovarian cancer. Brooke Ervin discusses the challenges of translating real-world evidence into actionable clinical decisions in urology, emphasizing the need for better integration of data into clinical workflows." datetime: "2026-05-06T18:15:43.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/285421024.md) - [en](https://longbridge.com/en/news/285421024.md) - [zh-HK](https://longbridge.com/zh-HK/news/285421024.md) --- # Welcome to _Pharmaceutical Executive Daily_, your quick briefing on the top news shaping the pharmaceutical and life sciences industry. In today's _Pharmaceutical Executive Daily_, Bayer agrees to acquire Perfuse Therapeutics for up to $2.45 billion and Madrigal obtains an exclusive global license for a precision siRNA therapy targeting a key genetic driver of MASH, Zentalis Pharmaceuticals announces the first patient dosed in a Phase III trial and Brooke Ervin argues that translating real-world evidence into commercial and clinical impact in urology requires more than access to data. Two pipeline-building are making news this week. Bayer has agreed to fully acquire Perfuse Therapeutics, a South San Francisco-based biopharmaceutical company developing PER-001 in a Phase II trial for glaucoma and diabetic retinopathy, for $300 million upfront and up to $2.45 billion in total consideration pending antitrust clearance and shareholder approval. In a separate deal, Madrigal Pharmaceuticals has entered into an exclusive global license agreement with Arrowhead Pharmaceuticals for ARO-PNPLA3, a clinical-stage GalNAc-conjugated siRNA targeting patatin-like phospholipase domain-containing protein 3, a key genetic driver of MASH that is highly prevalent among Hispanic patients for $25 million upfront and up to $975 million in milestones plus tiered royalties. Zentalis Pharmaceuticals has dosed the in the Phase III Aspenova clinical trial of a potentially first-in-class oral WEE1 inhibitor, in patients with Cyclin E1-positive platinum-resistant ovarian cancer. The trial is being conducted in collaboration with the GOG Foundation, the European Network of Gynaecological Oncological Trial groups, and the Asia-Pacific Gynecologic Oncology Trials Group, reflecting broad recognition of the unmet need in a patient population where options following platinum failure remain limited. Finally, Brooke Ervin why real-world evidence in urology so often stops short of actionable impact, arguing that access to data is only the first step in a much more demanding translation process. Ervin contends that the gap between generating RWE and embedding it in meaningful commercial or clinical decisions reflects structural failures in how data is contextualized, communicated, and connected to the workflows of the physicians and payers who need to act on it, and that closing that gap in a specialty as complex as urology, where treatment decisions span surgical, pharmacological, and watchful-waiting pathways, requires a more deliberate approach to evidence design from the outset. Thanks for listening to _Pharmaceutical Executive Daily_. For more updates and in-depth analysis, visit PharmExec.com. ### Related Stocks - [ZNTL.US](https://longbridge.com/en/quote/ZNTL.US.md) - [BAYRY.US](https://longbridge.com/en/quote/BAYRY.US.md) - [MDGL.US](https://longbridge.com/en/quote/MDGL.US.md) - [BAYN.DE](https://longbridge.com/en/quote/BAYN.DE.md) - [ARWR.US](https://longbridge.com/en/quote/ARWR.US.md) - [BAYZF.US](https://longbridge.com/en/quote/BAYZF.US.md) ## Related News & Research - [Bayer Introduces Midol® in Motion, Empowering Menstruators to Find PMS Relief Through Movement | BAYRY Stock News](https://longbridge.com/en/news/286570938.md) - [Bayer agrees to pay $133 million for PCB cleanup in two states](https://longbridge.com/en/news/286810928.md) - [What Madrigal Pharmaceuticals (MDGL)'s Wider Q1 Losses and Rezdiffra Revenue Momentum Mean For Shareholders](https://longbridge.com/en/news/286674743.md) - [Bayer Granted Priority Review For Asundexian In Secondary Stroke Prevention](https://longbridge.com/en/news/286884841.md) - [Bayer to buy Perfuse for up to $2.45B, bolstering eye drug pipeline](https://longbridge.com/en/news/285889049.md)