--- title: "U.S. stock market midday update: Regentis Biomaterials down 15.74% with significant capital outflow, increased volatility draws attention" type: "News" locale: "en" url: "https://longbridge.com/en/news/289629483.md" description: "Regentis Biomaterials fell 15.74%; Nuvalent fell 0.12%, with a transaction volume of USD 740 million; AbbVie rose 1.02%, with a transaction volume of USD 492 million; Amgen fell 0.17%, with a transaction volume of USD 426 million; Gilead Sciences fell 0.50%, with a market capitalization of USD 155.5 billion" datetime: "2026-06-12T18:22:35.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/289629483.md) - [en](https://longbridge.com/en/news/289629483.md) - [zh-HK](https://longbridge.com/zh-HK/news/289629483.md) --- # U.S. stock market midday update: Regentis Biomaterials down 15.74% with significant capital outflow, increased volatility draws attention **U.S. Stock Market Midday Update** Regentis Biomaterials fell 15.74%, with increased trading volume and no significant news recently. The trading is active, with clear capital flow. Considering the sector and industry trends, the stock shows significant volatility, and the specific reasons need further observation. **Stocks with High Trading Volume in the Industry** Nuvalent fell 0.12%, with increased trading volume. Based on recent key news: 1. On June 9, GlaxoSmithKline announced the acquisition of Nuvalent for $10.6 billion, leading to a historic high in stock price. This transaction has a 40% premium and is expected to be completed in the third quarter. Source: Sina Finance 2. On June 10, Nuvalent's analyst ratings were downgraded by several institutions, with the target price lowered to $124, affecting market confidence. Source: FactSet 3. On June 11, Nuvalent executives exercised options and sold shares, which may raise market concerns about internal confidence in the company. Source: EDGAR The biotechnology industry is active in mergers and acquisitions, leading to increased market volatility. AbbVie rose 1.02%, with increased trading volume. Based on recent key news: 1. On June 12, AbbVie presented its phase III trial data for venetoclax in treating chronic lymphocytic leukemia at the European Hematology Association annual meeting, showing long-term safety and efficacy. This positive result drove the stock price up. 2. On June 10, AbbVie received approval from the European Commission to expand the indication label for VENCLYXTO to include additional combinations for untreated chronic lymphocytic leukemia. This approval enhanced market confidence in its product line. 3. On June 12, Citigroup analyst Geoff Meacham maintained a hold rating on AbbVie and set a target price of $230, reflecting a cautious market attitude towards its valuation. Innovation in the pharmaceutical industry drives stock price volatility. Amgen fell 0.17%, with increased trading volume. Based on recent key news: 1. On June 12, Amgen is facing a challenge from the FDA's proposal to withdraw its rare disease drug Tavneos from the market. The FDA proposed withdrawal due to data integrity and safety issues, and Amgen has hired Duke Clinical Research Institute for an independent review, planning to submit detailed data on June 29. This event raised market concerns about drug safety, leading to stock price volatility. 2. On June 12, Amgen announced it would submit detailed data to support the safety and efficacy of Tavneos. Despite the FDA's concerns about the drug's safety, Amgen insists that the benefits of the drug outweigh the risks and plans to provide supporting data at the hearing on June 29. 3. On June 11, Morgan Stanley raised Amgen's target price from $332 to $340. Analysts are optimistic about the company's future growth prospects, maintaining confidence in its long-term performance despite regulatory challenges. The pharmaceutical industry faces regulatory challenges, leading to increased market volatility **Stocks Ranked Among the Top by Market Capitalization in the Industry** Gilead Sciences fell 0.50%. Based on recent key news: 1. On June 10, Gilead Sciences and Merck announced that their HIV treatment combination achieved primary efficacy endpoints in two studies and plan to submit Phase 3 results to global regulatory agencies. This news led to a 2.28% drop in Gilead Sciences' stock price. 2. On June 12, Gilead Sciences donated over 2,000 vials of Remdesivir to Uganda to support the response to the Ebola virus disease. This move failed to boost the stock price. 3. On June 12, Gilead Sciences completed the acquisition of Ouro Medicines, paying a $1.675 billion upfront payment and up to $500 million in potential milestone payments. Although this move demonstrates the company's determination to expand its business, the stock price did not see a significant increase. 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