---
title: "Buy Rating Reaffirmed on CNM-Au8 ALS Progress, Regulatory Momentum; $31 Price Target Maintained"
type: "News"
locale: "en"
url: "https://longbridge.com/en/news/295433920.md"
description: "H.C. Wainwright analyst Joseph Pantginis reaffirmed a Buy rating on Clene with a $31 price target, citing clinical and regulatory progress for its ALS asset CNM-Au8. New biomarker data linking neurofilament light chain reduction to survival outcomes addresses prior FDA feedback, strengthening the case for an NDA submission in Q4 2026 and potential accelerated approval."
datetime: "2026-08-10T16:35:30.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/295433920.md)
  - [en](https://longbridge.com/en/news/295433920.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/295433920.md)
generator: "portal-rs"
---

# Buy Rating Reaffirmed on CNM-Au8 ALS Progress, Regulatory Momentum; $31 Price Target Maintained

Joseph Pantginis, an analyst from H.C. Wainwright, maintained the Buy rating on Clene. The associated price target remains the same with $31.00.

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Joseph Pantginis has given his Buy rating due to a combination of factors tied to both clinical and regulatory progress for Clene’s lead asset, CNM-Au8, in ALS. He highlights newly reported biomarker data showing that reductions or stabilization in neurofilament light chain (NfL) are closely associated with longer survival and better functional outcomes, reinforcing NfL as a mechanistic and regulatory anchor for the program.

Pantginis also notes that these data appear to directly address prior FDA feedback by clearly linking the magnitude of NfL reduction to clinical benefit, thereby strengthening the company’s planned NDA submission in 4Q26 and its case for potential accelerated approval. He emphasizes that the NDA will be supported by a broad body of evidence from multiple trials and long-term datasets, which in his view “checks all the boxes” for a robust regulatory package and underpins his unchanged $31 price target and Buy recommendation. 

Pantginis covers the Healthcare sector, focusing on stocks such as Kura Oncology, Cytokinetics, and Rigel. According to TipRanks, Pantginis has an average return of 21.5% and a 52.34% success rate on recommended stocks.

### Related Stocks

- [CLNN.US](https://longbridge.com/en/quote/CLNN.US.md)
- [KURA.US](https://longbridge.com/en/quote/KURA.US.md)
- [CYTK.US](https://longbridge.com/en/quote/CYTK.US.md)
- [RIGL.US](https://longbridge.com/en/quote/RIGL.US.md)
- [CLNNW.US](https://longbridge.com/en/quote/CLNNW.US.md)

## Related News & Research

- [Clene to present at Cantor Global Healthcare Conference, host investor meetings](https://longbridge.com/en/news/297910510.md)
- [Clene says ALS biomarker analyses show CNM-Au8 survival benefit in NfL responders](https://longbridge.com/en/news/295404884.md)
- [Core & Main (CNM) Could Be 41% Undervalued As Its Growth Narrative Faces A Test](https://longbridge.com/en/news/298082569.md)
- [Clene Eyes Q4 NDA for ALS Drug After FDA-Requested Biomarker Analyses](https://longbridge.com/en/news/296405637.md)
- [Clene Targets Early Q4 NDA Filing for CNM-Au8 in ALS](https://longbridge.com/en/news/295645645.md)

---
> **Disclaimer: This article is for reference only and does not constitute any investment advice.**