---
title: "Weekly Recap | SPDR S&P Biotech +0.33%, mixed biotech tape"
type: "News"
locale: "en"
url: "https://longbridge.com/en/news/299504324.md"
description: "XBI.US finished the week at $156.72, up 0.33% from the previous Friday’s close of $156.20. Against the S&P 500’s 0.08% decline, the ETF outperformed by about 0.41 percentage points. Trading was choppy: the fund opened Monday at $156.86, hit a weekly high of $160.33, then slid to $152.50 on Wednesday before rebounding to $158.25 on Thursday. Friday pared some of that recovery, closing at $156.72. Weekly amplitude came to 4.99%, with average daily volume of around 9."
datetime: "2026-09-19T04:23:40.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/299504324.md)
  - [en](https://longbridge.com/en/news/299504324.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/299504324.md)
generator: "portal-rs"
---

# Weekly Recap | SPDR S&P Biotech +0.33%, mixed biotech tape

## The Week

XBI.US finished the week at $156.72, up 0.33% from the previous Friday’s close of $156.20. Against the S&P 500’s 0.08% decline, the ETF outperformed by about 0.41 percentage points. Trading was choppy: the fund opened Monday at $156.86, hit a weekly high of $160.33, then slid to $152.50 on Wednesday before rebounding to $158.25 on Thursday. Friday pared some of that recovery, closing at $156.72. Weekly amplitude came to 4.99%, with average daily volume of around 9.25 million shares, roughly 9% above the recent median.

## Sector News

The biotech complex lacked a clear directional driver this week, with activity concentrated in single names. Moderna jumped more than 7% on one session after positive Phase III melanoma data. On the other side, analysts rated Twist Bioscience a sell following its Lilly TuneLab collaboration, citing limited strategic upside and keeping a $45 target. Iovance Biotherapeutics traded at a premium after climbing 307%. Halozyme Therapeutics touched a 12-month high after upsizing its convertible notes to $1.3 billion, though a director also trimmed holdings. Separately, a growing Wall Street business is encouraging more biotechs to exit quietly, underscoring the squeeze on small and mid-cap names.

## The Week Ahead

The macro calendar turns to the first round of data after the Fed’s rate decision. Tuesday brings the Richmond Fed composite index, previously 4. Wednesday has EIA weekly crude and Cushing inventories. Thursday is heavier, with initial jobless claims, the current account balance, new home sales, and EIA natural gas storage all due. On the single-stock side, the event-driven momentum in Moderna, Natera, and Twist Bioscience will hinge on whether follow-on data or partnership updates materialise.

## In Short

XBI.US closed a volatile week with only a 0.33% gain, narrowly beating the broader market despite an intraday range of nearly 5%. Positive clinical news from Moderna sat alongside a sell rating on Twist Bioscience and convertible issuance from Halozyme, leaving the sector split between isolated strength and broader caution. The next move likely depends on whether the incoming macro data reinforces the repricing of the rate path, and whether individual biotech catalysts translate into sustained upside.

*This article is generated by LongbridgeAI from market data, for information only and not investment advice.*

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> **Disclaimer: This article is for reference only and does not constitute any investment advice.**