--- title: "TriSalus Life Sciences, Lakefront Biotherapeutics, Editas Medicine And Other Big Stocks Moving Higher On Wednesday" type: "News" locale: "en" url: "https://longbridge.com/en/news/299909622.md" description: "U.S. stocks fell with the Nasdaq dropping over 100 points, yet several biotech and tech shares rose. TriSalus surged 5.8% on FDA clearance for TriNav Advance. Lakefront Biotherapeutics gained 6.8% following an analyst upgrade to Outperform with a $45 price target. Other gainers included Securitize (+8.1%), Maze Therapeutics (+4.6%) after a Wedbush reiteration, Moderna (+4.4%) on ESMO Congress abstracts, Editas Medicine (+4%) on a Guggenheim upgrade, Xeris Biopharma (+3.4%), Palantir (+3.3%), and Pulse Biosciences (+3%) on BTIG initiation." datetime: "2026-09-23T14:02:59.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/299909622.md) - [en](https://longbridge.com/en/news/299909622.md) - [zh-HK](https://longbridge.com/zh-HK/news/299909622.md) generator: "portal-rs" --- # TriSalus Life Sciences, Lakefront Biotherapeutics, Editas Medicine And Other Big Stocks Moving Higher On Wednesday U.S. stocks were lower, with the Nasdaq Composite falling over 100 points on Wednesday. Shares of **TriSalus Life Sciences Inc** (NASDAQ:TLSI) rose sharply after the company announced it received FDA 510(k) clearance for TriNav Advance. TriSalus Life Sciences shares jumped 5.8% to $5.22 on Wednesday. Here are some other big stocks recording gains in today’s session. - **Securitize Corp** (NYSE:SECZ) shares jumped 8.1% to $14.04. - **Lakefront Biotherapeutics NV – ADR** (NASDAQ:LKFT) gained 6.8% to $32.24. RBC Capital analyst Brian Abrahams upgraded Lakefront Biotherapeutics from Sector Perform to Outperform and raised the price target from $26 to $45. - **Bandwidth Inc** (NASDAQ:BAND) gained 6.4% to $62.18. - **Maze Therapeutics In**c (NASDAQ:MAZE) surged 4.6% to $29.68. Wedbush analyst Laura Chico reiterated Maze Therapeutics with an Outperform rating and maintained a $48 price target. - **Moderna Inc** (NASDAQ:MRNA) rose 4.4% to $190.59. The company recently announced three abstracts on its mRNA-based individualized neoantigen therapy intismeran autogene have been accepted for presentation at the ESMO Congress 2026. - E**ditas Medicine Inc** (NASDAQ:EDIT) rose 4% to $3.04. Guggenheim analyst Debjit Chattopadhyay upgraded Editas Medicine from Neutral to Buy and announced a $5 price target. - **Xeris Biopharma Holdings In**c (NASDAQ:XERS) gained 3.4% to $9.03. - **Palantir Technologies Inc** (NASDAQ:PLTR) gained 3.3% to $191.00. - **Pulse Biosciences Inc** (NASDAQ:PLSE) gained 3% to $54.26. BTIG analyst Marie Thibault initiated coverage on Pulse Biosciences with a Buy rating and announced a PRICE TARGEt of $70. *Photo via Shutterstock* ### Related Stocks - [XERS.US](https://longbridge.com/en/quote/XERS.US.md) - [EDIT.US](https://longbridge.com/en/quote/EDIT.US.md) - [PLTR.US](https://longbridge.com/en/quote/PLTR.US.md) - [TLSI.US](https://longbridge.com/en/quote/TLSI.US.md) - [MAZE.US](https://longbridge.com/en/quote/MAZE.US.md) - [PLSE.US](https://longbridge.com/en/quote/PLSE.US.md) - [LKFT.US](https://longbridge.com/en/quote/LKFT.US.md) - [MRNA.US](https://longbridge.com/en/quote/MRNA.US.md) - [PLOO.US](https://longbridge.com/en/quote/PLOO.US.md) - [PTIR.US](https://longbridge.com/en/quote/PTIR.US.md) - [.IXIC.US](https://longbridge.com/en/quote/.IXIC.US.md) - [PLT.US](https://longbridge.com/en/quote/PLT.US.md) - [PLTU.US](https://longbridge.com/en/quote/PLTU.US.md) - [PLTW.US](https://longbridge.com/en/quote/PLTW.US.md) - [PLTG.US](https://longbridge.com/en/quote/PLTG.US.md) - [PLTD.US](https://longbridge.com/en/quote/PLTD.US.md) - [PLTZ.US](https://longbridge.com/en/quote/PLTZ.US.md) - [ONEQ.US](https://longbridge.com/en/quote/ONEQ.US.md) - [QQQ.US](https://longbridge.com/en/quote/QQQ.US.md) - [QQQM.US](https://longbridge.com/en/quote/QQQM.US.md) - [QQEW.US](https://longbridge.com/en/quote/QQEW.US.md) - [QQQE.US](https://longbridge.com/en/quote/QQQE.US.md) - [TQQQ.US](https://longbridge.com/en/quote/TQQQ.US.md) - [QLD.US](https://longbridge.com/en/quote/QLD.US.md) - [PSQ.US](https://longbridge.com/en/quote/PSQ.US.md) - [SQQQ.US](https://longbridge.com/en/quote/SQQQ.US.md) - [QID.US](https://longbridge.com/en/quote/QID.US.md) - [PLTA.US](https://longbridge.com/en/quote/PLTA.US.md) - [PLTY.US](https://longbridge.com/en/quote/PLTY.US.md) - [PLYY.US](https://longbridge.com/en/quote/PLYY.US.md) - [MRNX.US](https://longbridge.com/en/quote/MRNX.US.md) - [MRNY.US](https://longbridge.com/en/quote/MRNY.US.md) - [SECZ.US](https://longbridge.com/en/quote/SECZ.US.md) - [BAND.US](https://longbridge.com/en/quote/BAND.US.md) - [TLSIW.US](https://longbridge.com/en/quote/TLSIW.US.md) ## Related News & Research - [Palantir (PLTR) Has Over 1,000 Customers and Accelerating Growth. I'm Bullish](https://longbridge.com/en/news/300789910.md) - [Palantir Technologies Inc. $PLTR Stock Acquired by Defender Capital LLC.](https://longbridge.com/en/news/300735326.md) - [Moderna Stock Is Trending: What's Going On?](https://longbridge.com/en/news/300713446.md) - [Citi Downgrades Moderna Stock after 222% Rally, Calls Oncology Expectations "Unrealistic"](https://longbridge.com/en/news/300564590.md) - [Moderna loses US government license defense in Northwestern patent case](https://longbridge.com/en/news/300701587.md) --- > **Disclaimer: This article is for reference only and does not constitute any investment advice.**