---
title: "Top 10 US Stock Losers (10.29)"
type: "News"
locale: "en"
url: "https://longbridge.com/en/news/303637620.md"
description: "Iovance Biotherapeautics(IOVA) fell 35.45%, with a trading turnover 598.5 Million USD, and a year-to-date rose 250.2%. ServiceNow(NOW) fell 26.95%, with a trading turnover 8.6 Billion USD, and a year-to-date fell 28.4%. Alnylam Pharma(ALNY) fell 25.13%, with a trading turnover 2.2 Billion USD, and a year-to-date fell 56.2%."
datetime: "2026-10-29T22:01:11.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/303637620.md)
  - [en](https://longbridge.com/en/news/303637620.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/303637620.md)
generator: "portal-rs"
---

# Top 10 US Stock Losers (10.29)

NASDAQ Composite Index has fell 1.38%, with a year-to-date rose 12.7%; S&P 500 has fell 0.3%, with a year-to-date rose 12.8%; Dow Jones Industrial Average has fell 0.25%, with a year-to-date rose 8.9%.

Iovance Biotherapeautics(IOVA) fell 35.45%, with a trading turnover 598.5 Million USD, and a year-to-date rose 250.2%.

ServiceNow(NOW) fell 26.95%, with a trading turnover 8.6 Billion USD, and a year-to-date fell 28.4%.

Alnylam Pharma(ALNY) fell 25.13%, with a trading turnover 2.2 Billion USD, and a year-to-date fell 56.2%.

| Stock                          | Change  | Turnover          | Market Cap         | YTD Change |
| ------------------------------ | ------- | ----------------- | ------------------ | ---------- |
| Iovance Biotherapeautics(IOVA) | -35.45% | 598.5 Million USD | 4.3 Billion USD    | +250.2%    |
| ServiceNow(NOW)                | -26.95% | 8.6 Billion USD   | 113.4 Billion USD  | -28.4%     |
| Alnylam Pharma(ALNY)           | -25.13% | 2.2 Billion USD   | 23.3 Billion USD   | -56.2%     |
| Sprouts Farmers(SFM)           | -22.58% | 948.2 Million USD | 4.5 Billion USD    | -39.8%     |
| Fortinet(FTNT)                 | -20.09% | 2.3 Billion USD   | 102.1 Billion USD  | +75.2%     |
| Alkami Tech(ALKT)              | -18.29% | 100.3 Million USD | 1.4 Billion USD    | -45.0%     |
| Haleon(HLN)                    | -14.30% | 492.5 Million USD | 37.7 Billion USD   | -13.5%     |
| Aurora Innovation(AUR)         | -13.46% | 194.7 Million USD | 8.8 Billion USD    | +14.7%     |
| Marvell Tech(MRVL)             | -13.24% | 9.2 Billion USD   | 191.5 Billion USD  | +157.4%    |
| Alphabet(GOOGL)                | -12.64% | 39.5 Billion USD  | 3471.1 Billion USD | -9.1%      |

### Related Stocks

- [IOVA.US](https://longbridge.com/en/quote/IOVA.US.md)
- [NOW.US](https://longbridge.com/en/quote/NOW.US.md)
- [ALNY.US](https://longbridge.com/en/quote/ALNY.US.md)
- [SFM.US](https://longbridge.com/en/quote/SFM.US.md)
- [FTNT.US](https://longbridge.com/en/quote/FTNT.US.md)
- [ALKT.US](https://longbridge.com/en/quote/ALKT.US.md)
- [HLN.US](https://longbridge.com/en/quote/HLN.US.md)
- [AUR.US](https://longbridge.com/en/quote/AUR.US.md)
- [MRVL.US](https://longbridge.com/en/quote/MRVL.US.md)
- [GOOGL.US](https://longbridge.com/en/quote/GOOGL.US.md)

## Related News & Research

- [Will Earnings And Lung Cancer Data Change Iovance Stock Narrative](https://longbridge.com/en/news/305194421.md)
- [Alnylam Pharmaceuticals (ALNY) Is Up 5.4% What’s Changed After Five Year Drug Data](https://longbridge.com/en/news/305246964.md)
- [Alnylam Pharmaceuticals (ALNY) Faces A Valuation Test After Fresh AMVUTTRA Data](https://longbridge.com/en/news/304763201.md)
- [Fortinet (FTNT) Just Gave Investors Something To Think About](https://longbridge.com/en/news/305384927.md)
- [Iovance Biotherapeutics (IOVA) Reaffirmed Guidance And Shared Lifileucel Data, Is It 55% Undervalued?](https://longbridge.com/en/news/305356792.md)

---
> **Disclaimer: This article is for reference only and does not constitute any investment advice.**