Component stocks Applied Therapeutics rose 20.66%, Larimar Therapeutics Inc. rose 13.16%, Arcturus Therapeutics Holdings Inc. rose 10.47%, Abcellera Biologics rose 10.31%, and Design Therapeutics rose 9.93% ranking fifth. Astrazeneca ADR rose 6.6%, Regeneron Pharma rose 6.6%, and Moderna rose 6.4% performing well.

uniQure NV fell 5.14% ranking third from the bottom, Design Therapeutics fell 5.64%, and Enanta Pharmaceuticals also fell 13.78%