---
type: "Topics"
locale: "en"
url: "https://longbridge.com/en/topics/40128197.md"
description: "$XTALPI(02228.HK)SIGX2649 disclosed at AACR2026: globally leading pan-TEAD dual-blocking mechanism, nM-level full-subtype activity, >85% tumor inhibition rate in models such as mesothelioma/liver cancer, excellent safety window. As the second fully differentiated pipeline, it solidifies the replicability of the AI+organoid platform, with IND filings planned for both China and the US in Q2 2026."
datetime: "2026-04-23T07:55:33.000Z"
locales:
  - [en](https://longbridge.com/en/topics/40128197.md)
  - [zh-CN](https://longbridge.com/zh-CN/topics/40128197.md)
  - [zh-HK](https://longbridge.com/zh-HK/topics/40128197.md)
author: "[wolf-001](https://longbridge.com/en/profiles/15460724.md)"
---

# $XTALPI(02228.HK)SIGX2649 disclosed at AACR2026: g…


### Related Stocks

- [02228.HK](https://longbridge.com/en/quote/02228.HK.md)

## Comments (7)

- **五叶神 · 2026-04-24T07:54:27.000Z**: If it's just a rumor, why hasn't it rebounded to fill the gap? What's the panic about?
- **博客 · 2026-04-23T08:27:43.000Z**: Only you, Brother Wolf, are still holding on.
- **九五二七 · 2026-04-23T08:11:00.000Z**: There haven't been any negative news released, could it be following the Hang Seng's decline? 😂
  - **wolf-001** (2026-04-23T08:18:40.000Z): The characteristic of this stock is that there is too much short interest inventory, and the proportion of Stock Connect (for Hong Kong) is too high. It only requires a very small cost to push the pri
- **RextalPi · 2026-04-23T08:08:04.000Z**: Ignore the positive news. Please talk about some negative news, otherwise it's not worthy of this drop.
  - **wolf-001** (2026-04-23T08:10:20.000Z): Negative news: Retail investors have all fled.
  - **wolf-001** (2026-04-23T08:16:34.000Z): Short sellers can play however they want, aiming to drive the short interest ratio to 10%!