Day One Biopharmaceuticals Reports Three-Year Data Showing Durable Responses for OJEMDA in Pediatric Low-Grade Glioma

Reuters
2025.11.24 13:00
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Day One Biopharmaceuticals Inc. announced updated three-year follow-up data from the Phase 2 FIREFLY-1 trial of OJEMDA™ (tovorafenib) in pediatric low-grade glioma. Results showed 77% of patients remained off therapy for at least 12 months, with a median time to next treatment exceeding 3.5 years. The overall response rate was 53%, with a median duration of response of 19.4 months and median progression-free survival of 16.6 months. No new safety signals were identified.