<div id="readability-page-1"><div>Szwarcberg Javier B Chief Executive Officer of Spruce Biosciences Inc [SPRB] filed a Form 4 on December 12, 2025 with the Securities and Exchange Commission disclosing the following changes in ownership:<div><table><tbody><tr><th>Date</th><th>Transaction</th><th>Shares</th><th>Price</th><th>Value</th></tr><tr><td>12/10/25-12/11/25</td><td>Exercise</td><td>6,146</td><td>$0.00</td><td>N/A</td></tr><tr><td>12/10/25-12/11/25</td><td>Surrender(1)</td><td>2,622</td><td>$87.96</td><td>$230,638</td></tr></tbody></table></div>Ending Holdings: 12,998 - Direct<ul><li>(1)</li><li>Surrender of shares back to company to pay option exercise cost and/or resulting tax liability.</li></ul>For a free trial, or to learn more about our insider trading analysis and data services, please visit http://www.washingtonservice.com or contact us at (301) 913-5100 or send an email to info@washingtonservice.com.Founded in 1970, The Washington Service provides securities professionals with financial, economic and public policy research and data. </div></div>

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CEO Javier B Szwarcberg of Spruce Biosciences Inc acquired 3,524 shares, as disclosed in a Form 4 filed with the SEC on December 12, 2025. The transaction involved exercising 6,146 shares and surrendering 2,622 shares to cover option exercise costs and tax liabilities, resulting in direct holdings of 12,998 shares.

CEO Szwarcberg Acquires 3,524 Of Spruce Biosciences Inc [SPRB]