<div id="readability-page-1"><div>Gharib Samir M President of Spruce Biosciences Inc [SPRB] filed a Form 4 on December 12, 2025 with the Securities and Exchange Commission disclosing the following changes in ownership:<div><table><tbody><tr><th>Date</th><th>Transaction</th><th>Shares</th><th>Price</th><th>Value</th></tr><tr><td>12/10/25-12/11/25</td><td>Exercise</td><td>2,414</td><td>$0.00</td><td>N/A</td></tr><tr><td>12/10/25-12/11/25</td><td>Surrender(1)</td><td>864</td><td>$87.83</td><td>$75,882</td></tr></tbody></table></div>Ending Holdings: 7,616 - Direct<ul><li>(1)</li><li>Surrender of shares back to company to pay option exercise cost and/or resulting tax liability.</li></ul>For a free trial, or to learn more about our insider trading analysis and data services, please visit http://www.washingtonservice.com or contact us at (301) 913-5100 or send an email to info@washingtonservice.com.Founded in 1970, The Washington Service provides securities professionals with financial, economic and public policy research and data. </div></div>

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Gharib Samir M, President of Spruce Biosciences Inc, filed a Form 4 with the SEC, disclosing changes in ownership. He acquired 1,550 shares, exercised 2,414 shares, and surrendered 864 shares to cover option exercise costs and tax liabilities. His ending holdings are 7,616 shares directly. This event highlights insider trading activities within the company.

Pres Gharib Acquires 1,550 Of Spruce Biosciences Inc [SPRB]