--- title: "Sentynl and PRG partner for Progerinin licence" type: "News" locale: "en" url: "https://longbridge.com/en/news/279414537.md" description: "Sentynl Therapeutics has partnered with PRG S&T to license Progerinin, an investigational drug for treating Hutchinson-Gilford Progeria Syndrome (HGPS). The drug is currently in a Phase IIA trial, with results expected by mid-2026. Sentynl will gain full rights to Progerinin upon achieving specific milestones. This agreement enhances Sentynl's portfolio aimed at addressing rare diseases, reflecting their commitment to improving the lives of HGPS patients." datetime: "2026-03-17T09:50:56.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/279414537.md) - [en](https://longbridge.com/en/news/279414537.md) - [zh-HK](https://longbridge.com/zh-HK/news/279414537.md) --- # Sentynl and PRG partner for Progerinin licence The programme is completing a Phase IIA trial, with data expected before the end of H1 2026. Credit: Gorodenkoff / Shutterstock.com. Zydus Lifesciences subsidiary Sentynl Therapeutics has signed an agreement with Korean company PRG S&T to license Progerinin (SLC-D011), an investigational molecule intended to treat Hutchinson-Gilford Progeria Syndrome (HGPS). The move enables Sentynl to collaborate immediately with PRG S&T to advance clinical development of the molecule, which holds orphan drug status from the US Food and Drug Administration (FDA). ### Go deeper with GlobalData - ![ReportsLogo](/wp-content/themes/goodlife-wp-B2B/assets/img/report.png) Reports #### LOA and PTSR Model - Donaperminogene Seltoplasmid in Amyotrophic La... - ![ReportsLogo](/wp-content/themes/goodlife-wp-B2B/assets/img/report.png) Reports #### LOA and PTSR Model - PR-006 in Frontotemporal Dementia (FTD) ##### Go deeper with GlobalData The gold standard of business intelligence. Find out more #### Discover B2B Marketing That Performs Combine business intelligence and editorial excellence to reach engaged professionals across 36 leading media platforms. Find out more Sentynl will acquire full rights to Progerinin, provided certain milestones are achieved. The programme is presently completing a Phase IIA clinical trial, with data anticipated before the end of the first half of 2026. Upon closing, this therapy would become Sentynl’s second offering aimed at treating HGPS. Progerinin is an orally active small-molecule drug, which is being developed as a treatment for HGPS, a rare condition caused by mutations in the LMNA gene resulting in progerin accumulation and premature cellular ageing. The drug aims to inhibit progerin’s effects within cells, potentially improving nuclear integrity and reducing damage. GlobalData Strategic Intelligence # US Tariffs are shifting - will you react or anticipate? Don’t let policy changes catch you off guard. Stay proactive with real-time data and expert analysis. By GlobalData Learn more about Strategic Intelligence Progerinin is not currently approved by any health authority. Early research and clinical studies are designed to assess whether it can slow disease progression and improve survival in HGPS patients. Zydus Lifesciences managing director Dr Sharvil Patel said: “This acquisition marks an important step in growing our portfolio of therapies for Hutchinson-Gilford Progeria Syndrome, which can have severe impacts on patient health if left untreated. “Supporting patients in living healthy, fulfilled lives is core to what we do, and the agreement with PRG S&T directly furthers this mission by advancing orphan therapies for patients and families impacted by rare diseases.” Sentynl CEO Matt Heck said: “Children with Hutchinson-Gilford Progeria Syndrome face an unforgiving disease. However, we are seeing real progress in progeria research, with new science changing what’s possible. “This agreement, which will add Progerinin to our progeria portfolio, represents our commitment to translating that progress into another real therapy for children and families who need them.” In May 2024, Sentynl announced the worldwide acquisition of the Zokinvy (lonafarnib) programme from Eiger BioPharmaceuticals for the treatment of progeria. ### Related Stocks - [SBIO.US](https://longbridge.com/en/quote/SBIO.US.md) - [ZYXIQ.US](https://longbridge.com/en/quote/ZYXIQ.US.md) - [BBH.US](https://longbridge.com/en/quote/BBH.US.md) - [IBB.US](https://longbridge.com/en/quote/IBB.US.md) - [RSLS.US](https://longbridge.com/en/quote/RSLS.US.md) - [FBT.US](https://longbridge.com/en/quote/FBT.US.md) - [BIB.US](https://longbridge.com/en/quote/BIB.US.md) - [LABU.US](https://longbridge.com/en/quote/LABU.US.md) - [IHI.US](https://longbridge.com/en/quote/IHI.US.md) - [HIND.US](https://longbridge.com/en/quote/HIND.US.md) - [XBI.US](https://longbridge.com/en/quote/XBI.US.md) - [XHE.US](https://longbridge.com/en/quote/XHE.US.md) - [PBE.US](https://longbridge.com/en/quote/PBE.US.md) - [GLSI.US](https://longbridge.com/en/quote/GLSI.US.md) ## Related News & Research - [Top Executive Doubles Down on Greenwich LifeSciences With Fresh Insider Buy](https://longbridge.com/en/news/294443392.md) - [Medicare is about to change a drug program that held down the cost of premiums. 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