<div id="readability-page-1"><div> (RTTNews) - Pre-market trading is offering an early glimpse into biotech stocks likely to attract investor attention this Wednesday. Significant price moves ahead of the opening bell are being driven by clinical trial updates, public and private offerings and corporate developments. Assessing sentiment and momentum in the premarket sets the tone for a trader's day. In the Green - Premarket Gainers On Wednesday, the following stocks were trading significantly higher in the premarket session. 1. Picard Medical, Inc. (PMI) - up 34% at $0.36 2. Connect Biopharma Holdings Limited.(CNTB) - up 14% at $2.44 3. Rezolute, Inc. (RZLT) - up 8% at $4.31 4. Kairos Pharma, Ltd. (KAPA) - up 7% at $0.49 5. Nuwellis, Inc.. (NUWE) - up 8% at $0.64 6. LifeVantage Corporation. (LFVN) - up 10% at $9.46 7. Mustang Bio, Inc. (MBIO) - up 7% at $0.81 8. Profusa, Inc. (PFSA) - up 8% at $0.35 9. INVO Fertility, Inc. (IVF) - up 9% at $1.66 10. Actuate Therapeutics, Inc. (ACTU) - up 8% at $2.03 In the Red - Premarket Losers The following stocks were trading lower in the premarket session on Wednesday. 1. TransCode Therapeutics, Inc. (RNAZ) - down 22% at $4.13 2. Soligenix, Inc. (SNGX) - down 20% at $0.60 3. NRx Pharmaceuticals, Inc. (NRXP) - down 21% at $3.65 4. AIM ImmunoTech Inc. (AIM) - down 16% at $0.70 5. Basel Medical Group Ltd. (BMGL) - down 25% at $0.41 6. Bluejay Diagnostics, Inc.. (BJDX) - down 14% at $3.72 7. Dogwood Therapeutics, Inc. (DWTX) - down 7% at $1.75 8. Jin Medical International Ltd. (ZJYL) - down 10% at $2.93. 9. Aethlon Medical, Inc. (AEMD) - down 5% at $2.09 10. IceCure Medical Ltd. (ICCM) - down 6% at $0.13 For More Such Biotech Stock News, visit rttnews.com. The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc. </div></div>

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Pre-market biotech trading on Wednesday showed significant volatility driven by clinical updates and corporate developments. Gainers included Picard Medical (PMI) up 34%, Connect Biopharma (CNTB) up 14%, and LifeVantage (LFVN) up 10%. Losers featured TransCode Therapeutics (RNAZ) down 22%, Soligenix (SNGX) down 20%, and Basel Medical Group (BMGL) down 25%. These movements set the tone for the day's trading session.

Pre-Market Movers: PMI, CNTB, RNAZ Chart The Course