--- title: "Moderna nearly triples in record S&P 500 move, but analyst sees more volatility ahead" type: "News" locale: "en" url: "https://longbridge.com/en/news/296457881.md" description: "Moderna shares surged 176.97% to $174.38, marking the largest one-day gain for an S&P 500 stock this century, driven by positive late-stage results for its personalized mRNA cancer vaccine with Merck. The rally added $44B to its market cap, bringing it to $69.6B and making it the second-best performer in the index for the year. Despite the historic move, analyst Edmund Ingham maintained a Hold rating, citing the need for further clinical validation before full Phase 3 data release. Shares pulled back 14% in premarket trading Thursday as investors took profits." datetime: "2026-08-20T08:31:43.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/296457881.md) - [en](https://longbridge.com/en/news/296457881.md) - [zh-HK](https://longbridge.com/zh-HK/news/296457881.md) generator: "portal-rs" --- # Moderna nearly triples in record S&P 500 move, but analyst sees more volatility ahead ### Related Stocks - [MRNA.US](https://longbridge.com/en/quote/MRNA.US.md) - [MRK.US](https://longbridge.com/en/quote/MRK.US.md) - [MRNX.US](https://longbridge.com/en/quote/MRNX.US.md) - [MRNY.US](https://longbridge.com/en/quote/MRNY.US.md) ## Related News & Research - [Moderna stock soars on cancer vaccine success](https://longbridge.com/en/news/296405393.md) - [Moderna shares surge after it says its experimental mRNA cancer treatment passed a key test](https://longbridge.com/en/news/296382081.md) - [Health care roundup: Market talk](https://longbridge.com/en/news/296381776.md) - [Moderna's personalized mRNA shot could reshape the fight against skin cancer - but it may also be overhyped](https://longbridge.com/en/news/296527593.md) - [BioNTech’s rally on Moderna trial win likely to fade, Leerink says](https://longbridge.com/en/news/296380155.md) --- > **Disclaimer: This article is for reference only and does not constitute any investment advice.**