CNBC's Jim Cramer said Monday that Advanced Micro Devices' remarkable run under CEO Lisa Su is far from over, with the rise of agentic AI opening another major growth opportunity for the chipmaker.

"Lisa Su has orchestrated one of the greatest turnarounds in history at AMD, arguably the greatest of all time, and I see no sign that it's going to stop any time soon," the "Mad Money" host said.

AMD rallied nearly 13% last week and briefly surpassed $1 trillion in market cap before slipping back below the milestone Monday. The stock has gained almost 30% in September alone, with its latest surge fueled in part by Meta's launch of Muse, its personal AI agent platform. Cramer said the growing adoption of AI agents should drive significant demand for central processing units, a market where he said AMD "remains the leader."

"Earlier this year, the focus for investors shifted from AI model training to inference and agentics, and it became clear that demand for CPUs was going to explode, because you need more CPUs to run useful AI agents," Cramer said.

AMD's current position represents a remarkable reversal from when Su took over as CEO in October 2014. Back then, the company was worth just over $2.5 billion and losing market share to rival chipmaker Intel. Fast forward, and AMD shares have surged more than 18,000% as Su refocused the company and steadily gained share in CPUs.

While bolstering CPUs, AMD also carved out a foothold in the graphics processors used for AI workloads, taking on Nvidia in a market that Cramer said is large enough to support multiple winners. AMD has already secured major commitments for its GPUs from some of the biggest AI spenders, including Meta and OpenAI.

"Nvidia's still the top dog in AI chips, but AMD's making big money, too, and [Su's] products are more competitive than people think," he said. "Nvidia literally can't make their own chips fast enough to satisfy the demand. Of course there was room for AMD here."

Cramer acknowledged AMD's enormous run leaves it vulnerable to pullbacks, but AMD's long-term opportunity remains intact. "What an incredible run," he said. "Thanks to Lisa Su's understated, dogged, tenacious leadership, she transformed a $2.5 billion company into a nearly trillion-dollar powerhouse."

Cramer's Charitable Trust, the portfolio run by CNBC's Investing Club, owns shares of INTC, META, NVDA.

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