---
title: "Septerna, Inc. (SEPN.US)"
type: "quote"
locale: "en"
url: "https://longbridge.com/en/quote/SEPN.US.md"
symbol: "SEPN.US"
name: "Septerna, Inc."
industry: "制藥"
---

# Septerna, Inc. (SEPN.US)

| Item | Detail |
|------|--------|
| Industry | 制藥 |
| Location | 美股市場 |
| Website | [epterna.com](https://epterna.com) |

## Company Profile

Septerna, Inc.是一家臨床階段的生物技術公司，專注于發現和開發用于內分泌學、免疫學、炎症和代謝疾病治療的 G 蛋白偶聯受體（GPCR）口服小分子產品。該公司開發了 PTH1R 項目，口服小分子甲狀旁腺激素 1 受體激動劑用于治療甲狀旁腺功能減退症；SEP-631，一種口服小分子 MRGPRX2 負向別構調節劑（NAM），用于慢性自發性蕁麻疹和其他肥大細胞疾病；以及 TSHR 項目，一種口服小分子 TSHR NAM，用于格雷夫斯病和甲狀腺眼病。該公司還開發用于代謝紊亂的口服小分子單一和多重胰高血糖素樣肽受體激動劑，包括肥胖和 2 型糖尿病。此外，它還關注其他治療領域，包括神經學、女性...

## Financial Score

> *Longbridge Financial Score™ — Proprietary multi-factor rating model by [Longbridge](https://longbridge.com). This score is independently calculated by Longbridge and is not affiliated with any third-party rating agency.*
> Updated: 2026-03-01T04:30:12.000Z

**Overall: C (0.49)**

**Industry**: Pharmaceuticals

| Metric | Value |
|--------|-------|
| Industry Ranking | 65 / 188 |
| Industry Median | C |
| Industry Average | C |

- **Style**: Blend - Stocks in which the company has both growth and mature businesses.
- **Scale**: Small - The company's operation has a high degree of growth and volatility, making it easy to achieve high investment returns.

### Score Analysis

**Style Score**: 

#### Growth Score: 

| Indicator | Value | Rating |
|-----------|-------|--------|
| Revenue YoY | 2147.20% |  |
| Net Profit YoY | -196.28% |  |

#### Value Score: 

| Indicator | Value | Rating |
|-----------|-------|--------|
| P/B Ratio | 3.34 |  |
| Dividend Ratio | 0.00% |  |


**Size Score**: 

#### Market Cap Score: 

| Indicator | Value | Rating |
|-----------|-------|--------|
| Market Cap | 1.30B |  |

#### Revenue Score: 

| Indicator | Value | Rating |
|-----------|-------|--------|
| Revenue | 22.05M |  |


**Multi Score**: C

#### Profit Score: D

| Indicator | Value | Rating |
|-----------|-------|--------|
| ROE | -39.03% | E |
| Profit Margin | -266.77% | E |
| Gross Margin | 100.00% | A |

#### Growth Score: A

| Indicator | Value | Rating |
|-----------|-------|--------|
| Revenue YoY | 2147.20% | A |
| Net Profit YoY | -196.28% | E |
| Total Assets YoY | 248.09% | A |
| Net Assets YoY | 184.27% | A |

#### Cash Score: B

| Indicator | Value | Rating |
|-----------|-------|--------|
| Cash Flow Margin | -37.49% | D |
| OCF YoY | 2147.20% | A |

#### Operating Score: E

| Indicator | Value | Rating |
|-----------|-------|--------|
| Turnover | 0.06 | E |

#### Debt Score: B

| Indicator | Value | Rating |
|-----------|-------|--------|
| Gearing Ratio | 35.92% | B |


```chart-data:radar
{
  "title": "Longbridge Financial Score - Septerna, Inc.",
  "chart_type": "radar",
  "dimensions": [
    {
      "name": "Profit",
      "grade": "D",
      "indicators": [
        {
          "name": "ROE",
          "value": "-39.03%",
          "rating": "E"
        },
        {
          "name": "Profit Margin",
          "value": "-266.77%",
          "rating": "E"
        },
        {
          "name": "Gross Margin",
          "value": "100.00%",
          "rating": "A"
        }
      ]
    },
    {
      "name": "Growth",
      "grade": "A",
      "indicators": [
        {
          "name": "Revenue YoY",
          "value": "2147.20%",
          "rating": "A"
        },
        {
          "name": "Net Profit YoY",
          "value": "-196.28%",
          "rating": "E"
        },
        {
          "name": "Total Assets YoY",
          "value": "248.09%",
          "rating": "A"
        },
        {
          "name": "Net Assets YoY",
          "value": "184.27%",
          "rating": "A"
        }
      ]
    },
    {
      "name": "Cash",
      "grade": "B",
      "indicators": [
        {
          "name": "Cash Flow Margin",
          "value": "-37.49%",
          "rating": "D"
        },
        {
          "name": "OCF YoY",
          "value": "2147.20%",
          "rating": "A"
        }
      ]
    },
    {
      "name": "Operating",
      "grade": "E",
      "indicators": [
        {
          "name": "Turnover",
          "value": "0.06",
          "rating": "E"
        }
      ]
    },
    {
      "name": "Security",
      "grade": "B",
      "indicators": [
        {
          "name": "Gearing Ratio",
          "value": "35.92%",
          "rating": "B"
        }
      ]
    }
  ]
}
```

### Peer Comparison

| Rank | Name | Profit | Growth | Operation | Security | Cash | Rating |
|------|------|--------|--------|-----------|----------|------|--------|
| 01 | 禮來 (US.LLY) | A | A | B | E | B | B |
| 02 | ROCHE HOLDINGS AG (US.RHHVF) | A | B | B | D | C | B |
| 03 | 羅氏(ADR) (US.RHHBY) | A | B | B | D | C | B |
| 04 | 阿斯利康 (US.AZN) | A | B | C | D | C | B |
| 05 | 諾華制藥 (US.NVS) | A | B | C | D | C | B |

## Valuation Analysis

| Metric | Current | Industry Ranking | High | Median | Low |
|--------|---------|-----------------|------|--------|-----|
| PE (TTM) | -22.09 | 208/257 | - | - | - |
| PB | 3.34 | 118/257 | 3.00 | 1.71 | 1.11 |
| PS (TTM) | 58.94 | 139/257 | 743.09 | 305.07 | 55.61 |
| Dividend Yield | 0.00% | - | - | - | - |

## Institutional View

### Analyst Rating Distribution

> As of 2026-02-24T05:00:00.000Z

Total Analysts: **8**

| Rating | Count | Percentage |
|--------|-------|-----------|
| Buy | 7 | 88% |
| Overweight | 1 | 13% |
| Hold | 0 | 0% |
| Underweight | 0 | 0% |
| Sell | 0 | 0% |

### Target Price Forecast

| Metric | Price |
|--------|-------|
| Current Price | 29.02 |
| Highest Target | 43.00 |
| Lowest Target | 25.00 |

## References

- [Company Overview](https://longbridge.com/en/quote/SEPN.US/overview.md) - Shareholders, executives, business segments
- [Financials](https://longbridge.com/en/quote/SEPN.US/norm.md) - Income statement, balance sheet, cash flow, distribution plan
- [Topics & Discussions](https://longbridge.com/en/quote/SEPN.US/topics.md) - Community topics and discussions

---

> **Disclaimer**: This article is for reference only and does not constitute any investment advice.