--- title: "04:00 ET Ziwig Endotest®: Scientific Validation Published in NEJM Evidence" type: "News" locale: "zh-CN" url: "https://longbridge.com/zh-CN/news/268211083.md" description: "NEJM Evidence published a study validating Ziwig Endotest®, a saliva-based diagnostic test for endometriosis. The study showed high diagnostic performance with sensitivity at 97.3% and specificity at 94.1%. Now available in 100 hospitals in France, the test offers rapid, non-invasive diagnosis for women aged 18-43 with chronic pelvic pain. This marks a major advancement in women's health, reducing diagnostic delays for endometriosis." datetime: "2025-12-02T09:01:13.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/268211083.md) - [en](https://longbridge.com/en/news/268211083.md) - [zh-HK](https://longbridge.com/zh-HK/news/268211083.md) --- > 支持的语言: [English](https://longbridge.com/en/news/268211083.md) | [繁體中文](https://longbridge.com/zh-HK/news/268211083.md) # 04:00 ET Ziwig Endotest®: Scientific Validation Published in NEJM Evidence , /PRNewswire/ -- NEJM Evidence, a journal of the New England Journal of Medicine Group, has published an article titled "Validation of a Saliva microRNA Signature for Endometriosis," dedicated to the saliva-based diagnostic test developed by Ziwig. The publication reports the results of a prospective, independent, multicenter clinical study conducted in France. The study enrolled 971 symptomatic women aged 18 to 43 years across 17 public and private hospitals. **High-performance saliva-based diagnosis** The Ziwig Endotest® was evaluated through the analysis of 109 salivary microRNAs, combining next-generation sequencing (NGS) with artificial intelligence. Diagnostic interpretations were performed blindly, without prior knowledge of the patients' clinical status, ensuring full methodological independence and robustness. The NEJM Evidence publication highlights exceptional diagnostic performance: - **Sensitivity:** **97.3%** - **Specificity:** **94.1%** - **Overall accuracy:** **96.6%** - **Positive predictive value:** **98.2%** - **Negative predictive value:** **91.3%** These results show that **more than 96 out of 100 women receive an accurate diagnostic result with Ziwig Endotest®**. Performance remained consistent across all subgroups, regardless of hormonal treatment, analgesic use, inclusion site, or sequencing conditions, confirming the reliability and reproducibility of the test in real-world settings. **Now available for routine prescription in clinical practice** Within the framework of the French national early access program for breakthrough technologies (Forfait Innovation), Ziwig Endotest® is now reimbursed and available on medical prescription in 100 hospitals across France. It is indicated for women aged 18 to 43 years with chronic pelvic pain suggestive of endometriosis, when imaging results are normal or inconclusive. The test can be prescribed outside any research study, providing women with rapid, non-invasive, and accurate access to diagnosis. ** A major advance for women's health**Endometriosis affects around 10% of women of reproductive age, with diagnostic delays often exceeding seven years. The validation and clinical deployment of Ziwig Endotest® mark a major step forward toward earlier, simpler, and more equitable diagnosis. "_This publication in NEJM Evidence is a major step forward for science and for women affected by endometriosis. We are deeply grateful to all the women, hospitals, and healthcare professionals whose commitment and support have been essential in bringing this innovation to patients,"_ said Yahya El Mir, Founder and President of Ziwig. For more information: www.ziwig.com Contact presse – Finn Partners Marie-Hélène Coste & Aurélia Adloff 06 20 89 49 03 / 06 89 38 94 70 \[email protected\] Logo: https://mma.prnewswire.com/media/2835260/Ziwig\_Logo.jpg ## 相关资讯与研究 - [There’s Been A Staggering Number Of Deaths In ICE Custody During Trump’s Second Term](https://longbridge.com/zh-CN/news/281293924.md) - [08:57 ETn6 Launches icon16™, Expanding AutoNorm™ Adaptive Amplification to Lower-Throughput NGS Workflows](https://longbridge.com/zh-CN/news/280910944.md) - [ZAWYA: Cambridge Health Group announces 70 bed expansion of Cambridge Hospital Jeddah](https://longbridge.com/zh-CN/news/281484041.md) - [17:35 ETBedrock Bioscience Introduces Gazelle™ Chair, Offering a Breakthrough Non-Invasive Solution for Bladder Control and Pelvic Floor Strength](https://longbridge.com/zh-CN/news/281251968.md) - [06:37 ETPerry Endodontics Welcomes Dr. Joey Zeng to Its Westfield, MA Specialty Practice](https://longbridge.com/zh-CN/news/281508097.md)