---
title: "Shanghai Henlius Biotech Doses First Patient in Phase 1b/2 Trial of HLX43 Combination for Advanced Colorectal Cancer"
type: "News"
locale: "zh-CN"
url: "https://longbridge.com/zh-CN/news/275577160.md"
datetime: "2026-02-11T09:00:59.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/275577160.md)
  - [en](https://longbridge.com/en/news/275577160.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/275577160.md)
---

> 支持的语言: [English](https://longbridge.com/en/news/275577160.md) | [繁體中文](https://longbridge.com/zh-HK/news/275577160.md)


# Shanghai Henlius Biotech Doses First Patient in Phase 1b/2 Trial of HLX43 Combination for Advanced Colorectal Cancer

Shanghai Henlius Biotech Inc. has announced the dosing of the first patient in a phase 1b/2 clinical study evaluating HLX43, an anti-PD-L1 antibody-drug conjugate, in combination with either HLX07 (a recombinant anti-EGFR humanised monoclonal antibody) or HANSIZHUANG (serplulimab injection) in patients with advanced or metastatic colorectal cancer in mainland China. The study is designed to assess the safety, tolerability, and efficacy of the combination therapies. The trial includes a safety run-in stage with dose escalation, followed by a dose expansion stage. As of the date of the announcement, no results from the study have been presented. Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Shanghai Henlius Biotech Inc. published the original content used to generate this news brief via IIS, the Issuer Information Service operated by the Hong Kong Stock Exchange (HKex) (Ref. ID: HKEX-EPS-20260211-12021811), on February 11, 2026, and is solely responsible for the information contained therein. © Copyright 2026 - Public Technologies (PUBT)

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