---
title: "NIH halts low-dose rivaroxaban arm in stroke trial due to safety review findings in Phase 3 CAPTIVA trial."
type: "News"
locale: "zh-CN"
url: "https://longbridge.com/zh-CN/news/275803419.md"
description: "The NIH has halted the low-dose rivaroxaban arm of the Phase 3 CAPTIVA stroke prevention trial due to safety concerns. An independent review found increased safety events and no potential benefits compared to clopidogrel. The decision followed recommendations from the Data Safety and Monitoring Board, citing a predetermined futility threshold. Rivaroxaban is developed by Bayer AG and Johnson & Johnson."
datetime: "2026-02-12T20:00:45.000Z"
locales:
  - [zh-CN](https://longbridge.com/zh-CN/news/275803419.md)
  - [en](https://longbridge.com/en/news/275803419.md)
  - [zh-HK](https://longbridge.com/zh-HK/news/275803419.md)
---

> 支持的语言: [English](https://longbridge.com/en/news/275803419.md) | [繁體中文](https://longbridge.com/zh-HK/news/275803419.md)


# NIH halts low-dose rivaroxaban arm in stroke trial due to safety review findings in Phase 3 CAPTIVA trial.

The National Institutes of Health (NIH) has discontinued the low-dose rivaroxaban arm of its Phase 3 CAPTIVA stroke prevention trial. The trial aimed to compare the efficacy of experimental arms (rivaroxaban or ticagrelor, or both) against clopidogrel in reducing the 1-year rate of ischemic stroke, intracerebral hemorrhage, or vascular death. The decision came after an independent safety review revealed increased safety events and a lack of potential benefits. The NIH's National Institute of Neurological Disorders and Stroke, which sponsors the trial, acted on the recommendation of the Data Safety and Monitoring Board to halt the rivaroxaban group due to safety concerns and a predetermined futility threshold. Rivaroxaban is a product of Bayer AG and Johnson & Johnson. Full story on Benzinga.com.

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