--- title: "The wave of brain-computer interfaces has arrived. How is Shanghai leading the way?" type: "News" locale: "zh-CN" url: "https://longbridge.com/zh-CN/news/279155604.md" description: "Shanghai has gathered nearly 60 brain-computer interface companies, forming a complete industrial ecosystem. Bonree successfully obtained the world's first registration certificate for invasive brain-computer interface medical devices, marking the transition of this technology from the laboratory to clinical commercialization. At the national level, brain-computer interfaces have been listed as a key industry for cultivation, with broad prospects for future development" datetime: "2026-03-15T12:17:16.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/279155604.md) - [en](https://longbridge.com/en/news/279155604.md) - [zh-HK](https://longbridge.com/zh-HK/news/279155604.md) --- > 支持的语言: [English](https://longbridge.com/en/news/279155604.md) | [繁體中文](https://longbridge.com/zh-HK/news/279155604.md) # The wave of brain-computer interfaces has arrived. How is Shanghai leading the way? **"The Science and Technology Innovation Board Daily" March 15 report (Reporter Shi Shiyun)** Shanghai leads the national brain-computer interface industry. Recently, Shanghai brain-computer interface company Bonree successfully obtained the world's first Class III medical device registration certificate for invasive brain-computer interfaces. Its implanted hand motor function compensation system has officially been approved for market launch, breaking the long-standing stagnation of brain-computer interface technology in the research experimental stage and achieving the world's first leap from laboratory research and development to clinical commercialization in this field. Behind this milestone achievement is Shanghai's systematic cultivation of the brain-computer interface industry in recent years. According to interviews with reporters from "The Science and Technology Innovation Board Daily," as of now, **Shanghai has gathered nearly 60 brain-computer interface companies, covering three major technical routes: invasive, semi-invasive, and non-invasive, establishing a complete industrial ecosystem that spans core component research and development, technical breakthroughs, clinical translation verification, and commercialization,** creating a unique "Shanghai model" for the scaled development of this cutting-edge future industry. The wave of the brain-computer interface industry has arrived. At the national level, the 2026 government work report for the first time listed brain-computer interfaces alongside quantum technology, embodied intelligence, and 6G, clearly identifying them as future industries to be prioritized for national cultivation. ▌ **Priority for clinical application in top-tier hospitals that have completed clinical verification** "I am doing well now, better than before. I have no numbness, no spasms, and no muscle weakness. My hand function has significantly improved compared to before, and my overall physical condition is gradually improving. The recovery of my bowel and bladder function is also very noticeable. I hope that the next time I go to Shanghai, I will be able to stand up. I am incredibly excited to learn that Bonree's brain-computer interface product has been approved for market launch. This means that thousands of spinal injury patients will receive tangible help just like I did," said Xiao Dong, the first patient to undergo a brain-computer interface clinical trial implantation in Shanghai. In November 2024, 38-year-old Xiao Dong underwent a brain-computer interface implantation surgery at Huashan Hospital affiliated with Fudan University. At that time, he had been paralyzed for four years due to a car accident that caused cervical dislocation. The implanted product was NEO, a brain-computer interface product developed in collaboration with Professor Hong Bo's team from Tsinghua University's School of Biomedical Engineering, which has now been approved for market launch. So far, NEO has completed 36 clinical surgeries, including 4 feasibility clinical trials and 32 multi-center confirmatory clinical trials, and has completed clinical endpoint collection by the end of November 2025. Trial data shows that the grasping function of the participating patients has improved to varying degrees, and some patients have also shown signs of neural remodeling, regaining some neural function. Regarding when the product can be applied clinically after obtaining the certificate, **Bonree stated that it may prioritize applications in top-tier hospitals that have completed clinical verification, while the company will also consider further expanding the scope of indications during the research process.** Recently, **Bonree is also making a strong push into the capital market, having completed IPO counseling registration,** officially starting the listing process on the Science and Technology Innovation Board. In Bonree's last round of financing (Round D), it received support from Futen Capital under Shanghai Guotou and Pudong Science and Technology Innovation, further accelerating the company's "fast track" in the capital market **▌The clustering effect of brain-computer interface companies is becoming prominent** On the same day that the National Medical Products Administration announced the approval of NEO for listing, Shanghai-based brain-computer interface company Ladder Medical also officially announced the completion of a strategic financing of 500 million yuan. The financing was led by Alibaba, with Guotou Chuanghe participating, and existing shareholders including Tencent, Yuanlai Capital, Yuanhe Yuandian, Qiming Venture Partners, Eli Lilly Asia Fund, and Source Code Capital all increasing their investments. **Ladder Medical is also the first company in the brain-computer interface field to receive investments from the two major internet giants, Alibaba and Tencent.** Reporters from the Science and Technology Innovation Board Daily noted that Ladder Medical's latest financing also included the Guotou Xiandai Fund under Shanghai State-owned Assets. As a technology company focused on minimally invasive implanted brain-computer interfaces, Ladder Medical has differentiated its approach from the epidural technology route used by Bonree, exploring another invasive technology route that penetrates deeper into brain tissue, thereby laying out two major business directions: "brain control" and "neural regulation." It has independently developed ultra-flexible electrodes with a thickness of 1/100 of a hair and the world's smallest wireless brain-computer implant. ### 256-channel wireless high-throughput invasive brain-computer interface system (WRS02) Earlier this year, Ladder Medical completed the clinical implantation of the proposed 256-channel wireless high-throughput invasive brain-computer interface system (WRS02), which is also the first clinical trial of a 256-channel invasive brain-computer interface in China. Ladder Medical stated on its official WeChat account that it plans to launch a large-scale multi-center registration clinical trial in mid-2026, aiming to complete the enrollment and implantation of nearly 40 patients within the year. By the end of 2026, the total number of clinical implants is expected to approach or even exceed the total number of existing clinical trials by Neuralink, which is currently about 21 cases. Currently, the 256-channel wireless high-throughput invasive brain-computer interface system has entered the "green channel" for innovative medical devices of the National Medical Products Administration, and the industry expects this product to be approved for listing by 2028. In the field of neural regulation, Ladder Medical has developed a closed-loop ultra-low-damage deep brain stimulation system (deep brain stimulation system) based on ultra-flexible microelectrode technology. This system has completed 4 clinical research implantation surgeries, achieving functional verification, and plans to start clinical trials in 2027 to provide treatment options for patients with Parkinson's disease, epilepsy, and other conditions. In the brain-computer interface industrial cluster in Shanghai, the "hardcore" product breakthroughs are not limited to Bonree and Ladder Medical; several other companies have also secured important positions with innovative technological routes. Among them, Brain Tiger Technology completed the world's first prospective clinical trial of real-time Chinese language decoding, overcoming the industry challenge of the complexity of Chinese tones and the decoding difficulty far exceeding that of alphabetic languages, filling the gap in the field of real-time brain-computer decoding for tonal languages with a Chinese solution. Based on the transformation of Fudan University's scientific research achievements, Shenfu Jianxing successfully completed the first batch of domestic brain-spinal interface IIT trials around the world's first "three-in-one" brain-spinal interface technology, achieving phased success, and this product has entered the "breakthrough therapy" pathway of the U.S. FDA In the non-invasive track, Shanghai has also produced several local star enterprises, including Shuli Innovation, which has developed an "artificial intelligence multimodal brain-computer interface platform," Siyi Intelligent, which is deeply engaged in the field of neurological rehabilitation and has several products approved for market, and Aoyi Technology, which masters two core underlying technologies of brain-computer interfaces and robotics. **Some of the products of these companies have begun to be applied in clinical scenarios such as stroke rehabilitation, depression screening, and insomnia treatment, achieving sales on a scale of tens of millions.** ▌ **"Deeply Cultivating the Industry" Ecosystem** The accelerated "fast running" of local brain-computer interface companies and the "explosive" development of new technologies and products have jointly made Shanghai the first to become a global innovation source for the full technological route of brain-computer interfaces. In this fertile "soil" of innovation vitality, what has been done right in terms of industrial layout and ecosystem building? According to industry researcher Lin Kaiyu (pseudonym), Shanghai's advantages in the development of the brain-computer interface industry are multiple compared to other cities. "Brain-computer interface technology is a typical cross-disciplinary frontier technology, covering multiple fields such as neuroscience, artificial intelligence and machine learning, materials science, chip technology, and biomedical engineering, with a high demand for composite talents. **Shanghai has a deep accumulation in attracting, cultivating, and retaining high-end talents, gathering a large number of top scientific research talents and professional technical backbones. The scale of talent reserves and professional adaptability are both among the top in the country, providing the first layer of intellectual support for the research and development and transformation of brain-computer interface technology. The talent advantage is the core advantage that enables Shanghai's layout of the brain-computer interface industry to thrive.** In addition, Lin Kaiyu pointed out to the "Science and Technology Innovation Board Daily" reporter that the brain-computer interface industry does not develop independently in a single field; it requires a high degree of completeness and integration of regional industrial support. **As a national highland for industrial development, Shanghai has a well-established and mature layout of three leading industries, focusing on a large number of enterprises in biomedicine, chip research and development, artificial intelligence, large model algorithms, and integrated circuits, which have already formed a high-quality industrial ecosystem with a full chain and diversification.** "This is equivalent to adding a layer of fertilizer to already fertile soil, **not only allowing companies in the brain-computer interface field to more efficiently connect with upstream and downstream partners, smoothly carry out cross-field industrial collaboration, effectively unblock the bottlenecks and breakpoints in the industrial chain, and accelerate technological iteration, but also significantly reduce the R&D and production costs for enterprises."** Lin Kaiyu stated. As Lin Kaiyu mentioned, the solid ecological foundation has strengthened the confidence and accumulated momentum for the development of brain-computer interfaces. Taking the biomedicine industry, one of Shanghai's three leading industries, as an example, in recent years, Shanghai has focused on the goal of "building a global innovation source for biomedicine and a world-class industrial cluster," adhering to the full-process innovation and full-chain acceleration of "R&D + clinical + manufacturing + application," and accelerating the high-quality development of the biomedicine industry. Data shows that by 2025, the scale of Shanghai's biomedicine industry will grow against the trend, **with the industry scale breaking through the 1 trillion yuan mark for the first time,** and the output value of the biomedicine manufacturing industry reaching nearly 210 billion yuan, a year-on-year increase of 2.4%. **The output value proportion of innovative drug and device companies has increased to 20.9%,** up 12.8 percentage points from 2020 Lin Kaiyu also believes that Shanghai has gathered numerous top-tier Class A medical institutions and a number of prestigious research institutes, which possess domestic top-level standards in the fields of neurological medical treatment and scientific research. These **high-quality medical and research resources provide professional support for the research and development testing, clinical validation, and practical application of brain-computer interface products, which can accelerate the transformation of technological achievements into clinical applications and achieve a closed-loop development of industry, academia, and research.** At this stage, Shanghai has connected high-quality research resources, clinical institutions, and other upstream and downstream links, collaborating with Fudan University, Shanghai Jiao Tong University, the Brain Intelligence Excellence Center of the Chinese Academy of Sciences, and Huashan Hospital affiliated with Fudan University to layout and build key laboratories and public service platforms, establishing a professional testing system for brain-computer interfaces, and leading the formulation of China's first industry standards for medical devices related to brain-computer interfaces, cultivating an innovative ecosystem deeply integrated with industry, academia, research, and medicine. In addition, Shanghai has created the country's first future industry cluster for brain-computer interfaces, "Brain Intelligence World," leveraging the geographical advantages of the Hongqiao International Open Hub to construct a cross-regional resource network covering the Yangtze River Delta, aiming to gradually form a national-level community for the development of the brain-computer interface industry. In January 2025, the "Shanghai Brain-Computer Interface Future Industry Cultivation Action Plan (2025-2030)" was officially released, outlining a clear vision for industrial development. The aforementioned brain-computer interface action plan clearly focuses on medical-grade scenarios and strategic products, emphasizing the acceleration of the application of invasive and semi-invasive brain-computer interface technologies and products, encouraging the expansion of non-invasive technologies across multiple fields, while guiding financial capital to increase investment in cutting-edge technology research and development to assist companies in going public and financing. This plan is not only the first brain-computer interface special action plan reviewed and released by a provincial government in China but also Shanghai's first action plan in a future industry subfield. Industry analysis suggests that from research collaboration to clinical implementation, from policy guidance to capital support, Shanghai is cultivating an "industrial rainforest" with a "holistic" ecological mindset, suitable for the emergence, growth, and maturation of cutting-edge innovations. In the high-barrier future industry track of brain-computer interfaces, Shanghai may have initially forged a distinctive development path that combines technological innovation with commercial implementation ### 相关股票 - [Sanbo (301293.CN)](https://longbridge.com/zh-CN/quote/301293.CN.md) - [Bonree (688229.CN)](https://longbridge.com/zh-CN/quote/688229.CN.md) ## 相关资讯与研究 - [Tauns Laboratories Slashes Full-Year Forecast as Infection Waves Ease](https://longbridge.com/zh-CN/news/280977910.md) - [A C-Suite executive at Pop Mart's biggest Chinese competitor explains what goes into making a hit toy like Labubu](https://longbridge.com/zh-CN/news/281606541.md) - [Tesla Sold Over 358K Vehicles Globally In Q1, BYD Nearly Matches Total For Just Exports](https://longbridge.com/zh-CN/news/281564232.md) - [BYD Sales Down 20.4% in March](https://longbridge.com/zh-CN/news/281569871.md) - [BYD launches first overseas SkyRail project with Brazil monorail](https://longbridge.com/zh-CN/news/281523660.md)