---
title: "德琪醫藥公佈 ATG-022 治療胃癌 ORR 42.9% 的最新 I/II 期臨牀數據"
description: "德琪醫藥公佈 ATG-022 治療晚期或轉移性胃癌的最新 I/II 期臨牀數據，ORR 為 42.9%。該藥物是一種抗體偶聯藥物，針對 CLDN18.2 蛋白，顯示出良好的臨牀療效。ATG-022 已獲得 FDA 的孤兒藥資格，適用於胃癌和胰腺癌。"
type: "news"
locale: "zh-HK"
url: "https://longbridge.com/zh-HK/news/225792440.md"
published_at: "2025-01-22T07:25:34.000Z"
---

# 德琪醫藥公佈 ATG-022 治療胃癌 ORR 42.9% 的最新 I/II 期臨牀數據

> 德琪醫藥公佈 ATG-022 治療晚期或轉移性胃癌的最新 I/II 期臨牀數據，ORR 為 42.9%。該藥物是一種抗體偶聯藥物，針對 CLDN18.2 蛋白，顯示出良好的臨牀療效。ATG-022 已獲得 FDA 的孤兒藥資格，適用於胃癌和胰腺癌。

德琪醫藥今日宣佈，公司於 2025 年美國臨牀腫瘤學會胃腸道腫瘤研討會上公佈正在中國和澳大利亞進行中的臨牀 I/I 期評估 ATG-022 治療晚期或轉移性胃癌患者的 CLINCH 研究的最新數據。ATG-022 是一款被作用於 CLDN18.2 這一緊密連接蛋白的抗體偶聯藥物，而緊密連接蛋白屬於一種細胞黏附分子。美國食品藥品監督管理局授予了 ATG-022 兩項孤兒藥資格認定，分別用於治療胃癌和胰腺癌。來自正在開展的 CLINCH 研究的數據顯示，ATG-022 在不同 CLDN18.2 表達水平的胃癌患者中均顯示出良好的臨牀療效。目前在 CLDN18.2 不同表達水平的胃癌人羣中顯示出的療效提示 ATG-022 有望成為一款極具競爭力的藥物。

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