--- title: "03:15 ETgenOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model" type: "News" locale: "zh-HK" url: "https://longbridge.com/zh-HK/news/277004187.md" description: "genOway has developed a unique mouse model, genO-hFcγR, which enhances the prediction of therapeutic antibody efficacy and safety in humans. This model addresses the discrepancies in antibody therapies tested in standard laboratory mice, which often lead to late-stage clinical trial failures. The study, published in Science Immunology, involved an international consortium of biopharmaceutical partners and aims to accelerate drug development by providing early insights into antibody candidates. The genO-hFcγR model has been adopted by various biopharmaceutical companies and organizations since its launch in 2024." datetime: "2026-02-26T08:15:36.000Z" locales: - [zh-CN](https://longbridge.com/zh-CN/news/277004187.md) - [en](https://longbridge.com/en/news/277004187.md) - [zh-HK](https://longbridge.com/zh-HK/news/277004187.md) --- > 支持的語言: [简体中文](https://longbridge.com/zh-CN/news/277004187.md) | [English](https://longbridge.com/en/news/277004187.md) # 03:15 ETgenOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model , /PRNewswire/ -- Antibody therapies are changing the treatment of cancer, inflammatory diseases and infections. However, many promising drug candidates fail in clinical trials. A study in Science Immunology shows that genOway's genO-hFcγR mouse model enables more accurate prediction of therapeutic antibody efficacy and safety. **Why Antibody Therapies Fail in Late-Stage Testing** Continue Reading genOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model genOway: Revolutionizing the Prediction of Antibody Therapies in Humans with Unique Mouse Model Antibody therapies work in part by binding to Fcγ receptors, proteins found on immune cells that control key immune functions such as antibody-mediated cell killing and inflammation. Since these receptors are different between species, human therapies tested in standard laboratory mice give unreliable efficacy results or miss potential safety risks. These discrepancies cause expensive late-stage failures and slow patient access to new therapies. **A New Mouse Model with Humanized Fcγ Receptors Set to Become a Gamechanger** A new study published in Science Immunology showed that an innovative mouse model developed by genOway, genO-hFcγR, helps scientists better predict the efficacy and safety of therapeutic antibodies in humans. The model allows scientists to rank different antibody candidates by how they are likely to perform, measure how effectively they target specific immune cells, and evaluate their potential to slow disease progression. This gives researchers key early insights to guide decisions and accelerate drug development. Video on genO-hFcγR mice: https://www.youtube.com/watch?v=H7xO-xGJV8Q Read the publication: https://www.science.org/doi/10.1126/sciimmunol.ady7328 **A Complex Scientific Challenge Achieved Through International Collaboration** Due to the species-specific nature of Fcγ receptors, developing this model demanded multidisciplinary expertise in mouse genetics, antibody biology, and human immunology. The achievement was made possible through an international consortium of leading biopharmaceutical partners, led by genOway, who combined their knowledge to co-develop and co-validate the genO-hFcγR mouse model. Consortium members included genOway (France), a company specializing in developing highly predictive preclinical models; argenx (Belgium), a pioneer in Fc-engineering and FcRn biology; Innate Pharma (France), a leader in natural killer cell-based immunotherapies; and Vir Biotechnology (USA), focused on the development of immunotherapies; among other members. The group collaborated with VIB-Ghent University (Belgium), a leading immunology institute, to publish the study in Science Immunology. In this study, scientists at VIB-Ghent University mapped Fc receptor expression and regulation to illustrate how the new mouse model could be used to better model human disease and coordinated the publication of the work. **A Unique Solution Available for the Scientific Community** The genO–hFcγR model builds on a previous mouse model developed in 2008 by genOway and its scientific partners, in which multiple FcγR genes were humanized. Since its launch to the scientific community in 2024, genO-hFcγR has been adopted to advance preclinical programs of biopharmaceutical companies and nonprofit organizations, including the Gates Foundation, as one of the foundation's global health research initiatives. Read the Gates Foundation press release at https://www.genoway.com/news-events/genoway-gates-foundation-2025 **About genOway **genOway is a biotechnology company that provides highly predictive preclinical models and solutions to biopharmaceutical companies, CROs and academic institutions to bridge the gap between preclinical findings and clinical success. More information at _genoway.com_. **Contact **Ana REZA Marketing Communications Manager \[email protected\] Image - https://mma.prnewswire.com/media/2918508/genOway\_1.jpg Image - https://mma.prnewswire.com/media/2918506/genOway\_2.jpg Logo - https://mma.prnewswire.com/media/2918507/5819376/genOway\_Logo.jpg ### 相關股票 - [Direxion S&P Biotech Bull 3X (LABU.US)](https://longbridge.com/zh-HK/quote/LABU.US.md) - [Invesco Nasdaq Biotechnology ETF (IBBQ.US)](https://longbridge.com/zh-HK/quote/IBBQ.US.md) - [VanEck Biotech ETF (BBH.US)](https://longbridge.com/zh-HK/quote/BBH.US.md) - [SPDR S&P Biotech (XBI.US)](https://longbridge.com/zh-HK/quote/XBI.US.md) - [ALPS Medical Breakthrough (SBIO.US)](https://longbridge.com/zh-HK/quote/SBIO.US.md) - [iShares US Pharma (IHE.US)](https://longbridge.com/zh-HK/quote/IHE.US.md) - [Proshares Ultra Nasdaq Biotech (BIB.US)](https://longbridge.com/zh-HK/quote/BIB.US.md) - [First Trust NYSE Arca Biotech Index Fd (FBT.US)](https://longbridge.com/zh-HK/quote/FBT.US.md) - [VG Health (VHT.US)](https://longbridge.com/zh-HK/quote/VHT.US.md) - [Proshares UltraShort Nasdaq Biotech (BIS.US)](https://longbridge.com/zh-HK/quote/BIS.US.md) - [iShares Biotechnology ETF (IBB.US)](https://longbridge.com/zh-HK/quote/IBB.US.md) - [Health Care Select Sector SPDR (XLV.US)](https://longbridge.com/zh-HK/quote/XLV.US.md) - [Invesco Biotechnology & Genome ETF (PBE.US)](https://longbridge.com/zh-HK/quote/PBE.US.md) - [Ark Genomic Revolution ETF (ARKG.US)](https://longbridge.com/zh-HK/quote/ARKG.US.md) ## 相關資訊與研究 - [C4 Therapeutics Maps Accelerated Approval Path for Myeloma Drug Cemsidomide at TD Cowen Conference](https://longbridge.com/zh-HK/news/278227263.md) - [BUZZ-Erasca rises on partnership with Tango to test new cancer drug combo](https://longbridge.com/zh-HK/news/277972424.md) - [Nuvau Minerals Raises $21.4 Million in Final Tranche of Brokered Financing](https://longbridge.com/zh-HK/news/278136148.md) - [AbbVie's Early Obesity Drug Data Shows Up To 10% Weight Loss](https://longbridge.com/zh-HK/news/278409007.md) - [Lexaria Launches 2026 R&D Push to Advance GLP-1 and Cannabidiol Drug Delivery](https://longbridge.com/zh-HK/news/277804860.md)