<div id="readability-page-1"><div>RNS Number : 1082U PureTech Health PLC 05 August 2025 TR-1: Standard form for notification of major holdings1. Issuer DetailsISINGB00BY2Z0H74Issuer NamePURETECH HEALTH PLCUK or Non-UK IssuerUK2. Reason for NotificationAn event changing the breakdown of voting rights3. Details of person subject to the notification obligationNameInvesco Ltd.City of registered office (if applicable)AtlantaCountry of registered office (if applicable)USA4. Details of the shareholderFull name of shareholder(s) if different from the person(s) subject to the notification obligation, aboveCity of registered office (if applicable)Country of registered office (if applicable)5. Date on which the threshold was crossed or reached01-Aug-20256. Date on which Issuer notified05-Aug-20257. Total positions of person(s) subject to the notification obligation<div><table><tbody><tr><td></td><td>% of voting rights attached to shares (total of 8.A)</td><td>% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)</td><td>Total of both in % (8.A + 8.B)</td><td>Total number of voting rights held in issuer</td></tr><tr><td>Resulting situation on the date on which threshold was crossed or reached</td><td>16.995075</td><td>0.000000</td><td>16.995075</td><td>41011890</td></tr><tr><td>Position of previous notification (if applicable)</td><td>17.142104</td><td>0.161018</td><td>17.303122</td><td></td></tr></tbody></table></div>8. Notified details of the resulting situation on the date on which the threshold was crossed or reached8A. Voting rights attached to shares<div><table><tbody><tr><td>Class/Type of shares ISIN code(if possible)</td><td>Number of direct voting rights (DTR5.1)</td><td>Number of indirect voting rights (DTR5.2.1)</td><td>% of direct voting rights (DTR5.1)</td><td>% of indirect voting rights (DTR5.2.1)</td></tr><tr><td>GB00BY2Z0H74</td><td></td><td>41011890</td><td></td><td>16.995075</td></tr><tr><td>Sub Total 8.A</td><td colspan="2">41011890</td><td colspan="2">16.995075%</td></tr></tbody></table></div>8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))<div><table><tbody><tr><td>Type of financial instrument</td><td>Sub Total 8.B1</td></tr><tr><td>Expiration date</td><td colspan="2"></td></tr><tr><td>Exercise/conversion period</td><td></td></tr><tr><td>Number of voting rights that may be acquired if the instrument is exercised/converted</td><td></td></tr><tr><td>% of voting rights</td></tr></tbody></table></div>8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))<div><table><tbody><tr><td>Type of financial instrument</td><td>Sub Total 8.B2</td></tr><tr><td>Expiration date</td><td colspan="3"></td></tr><tr><td>Exercise/conversion period</td><td></td></tr><tr><td>Physical or cash settlement</td><td></td></tr><tr><td>Number of voting rights</td></tr><tr><td>% of voting rights</td></tr></tbody></table></div>9. Information in relation to the person subject to the notification obligation2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)<div><table><tbody><tr><td>Ultimate controlling person</td><td>Invesco Ltd.</td></tr><tr><td>Name of controlled undertaking</td><td>Invesco Asset Management Limited</td></tr><tr><td>% of voting rights if it equals or is higher than the notifiable threshold</td><td>16.995075</td></tr><tr><td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td><td>0.000000</td></tr><tr><td>Total of both if it equals or is higher than the notifiable threshold</td><td>16.995075%</td></tr></tbody></table></div>10. In case of proxy votingName of the proxy holderThe number and % of voting rights heldThe date until which the voting rights will be held11. Additional InformationPlease note that the disclosure threshold was crossed due to a change in Total Voting rights. Refer to section 9 for detail of proxy holder's and % of voting rights held. Voting authority is held until it is revoked by the client/ the relevant Investment Management Agreement is terminated.12. Date of Completion05-Aug-202513. Place Of CompletionHenley-on-ThamesThis information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. 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PRTC

PureTech Health PLC announced a change in major holdings, with Invesco Ltd. crossing the notification threshold on August 1, 2025. Invesco now holds 16.995075% of the voting rights in the company, a decrease from the previous holding of 17.142104%. The notification was made on August 5, 2025, following a change in total voting rights. The information is provided by RNS, the news service of the London Stock Exchange.

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