NASDAQ Composite Index has rose 0.94%, with a year-to-date rose 15.7%; S&amp;P 500 has rose 0.47%, with a year-to-date rose 12.5%; Dow Jones Industrial Average has rose 0.11%, with a year-to-date rose 7.8%.Eightco(ORBS) fell 23.05%, with a trading turnover 50.4 Million USD, and a year-to-date rose 448.9%.
Stride(LRN) fell 11.75%, with a trading turnover 443.5 Million USD, and a year-to-date rose 34.5%.
Avidity Biosciences(RNA) fell 10.1%, with a trading turnover 223.0 Million USD, and a year-to-date rose 38.3%.<img src="https://pub.pbkrs.com/screenshot/us_decrease_top_ten_2025-09-16_en-1757973641062810264.png?x-oss-process=style/lg" original-src="https://pub.pbkrs.com/screenshot/us_decrease_top_ten_2025-09-16_en-1757973641062810264.png"/>

ORBS

Eightco(ORBS) fell 23.05%, with a trading turnover 50.4 Million USD, and a year-to-date rose 448.9%. Stride(LRN) fell 11.75%, with a trading turnover 443.5 Million USD, and a year-to-date rose 34.5%. Avidity Biosciences(RNA) fell 10.1%, with a trading turnover 223.0 Million USD, and a year-to-date rose 38.3%.

Top 10 US Stock Losers (9.15)