<div id="readability-page-1"><div>BOCA RATON, FL / ACCESS Newswire / September 16, 2025 / For a small-cap biotech, the headlines often center on fundraising, partnerships, or meeting exchange requirements. But every so often, the spotlight shifts to the science itself. Especially when it's the kind with the potential to rewrite how cancer is treated. That is where LIXTE Biotechnology Holdings finds itself today.Earlier this month, the company put the focus squarely on its lead compound, LB-100. It is the only clinical-stage inhibitor of protein phosphatase 2A (PP2A), a cellular enzyme that cancers hijack to survive treatment. That exclusivity is more than a scientific curiosity; it is the kind of value driver that can turn a small-cap biotech into a category creator.So why does PP2A matter? Think of it as the circuit breaker in cancer's wiring system. When therapies cause DNA damage or stress inside a tumor cell, PP2A shuts things down, giving the cell a chance to recover. Most treatments try to kill cancer directly. LB-100 takes a different approach: it disables the breaker, stripping cancer of its emergency escape route and leaving cells defenseless against therapy.Cancer's Most Lethal EnemySaid more directly, LB-100 drives tumors into a death spiral, pushing them into lethal overdrive until their own survival systems collapse. In other words, it becomes cancer's most lethal enemy. By inhibiting PP2A, LB-100 disrupts cancer's ability to repair itself, floods cells with stress signals, and even generates neoantigens that expose tumors to the immune system. In effect, it turns cold, invisible cancers into hot targets for immunotherapy.This dual punch-forcing self-destruction while making tumors more visible-sets LB-100 apart. It is not just a weapon on its own but an amplifier for existing treatments. When combined with chemotherapy, radiation, or immunotherapy, LB-100 is showing potential to strip away resistance and reveal tumors that were once untouchable.That is a particularly big deal-better yet, potentially life-saving-for patients with microsatellite stable colorectal cancer, which accounts for about 85% of colorectal cases. For these patients, immunotherapies that transformed other cancer types often fall short. The same is true for ovarian clear-cell carcinoma, another notoriously resistant tumor. LIXTE is betting that LB-100 can change that outcome.And LIXTE is not making that bet alone.Global Pharma Partners Join the MissionThrough a partnership with GSK, LIXTE is studying LB-100 in ovarian clear-cell carcinoma alongside Dostarlimab, with GSK funding the trial. At the same time, Roche is providing atezolizumab and trial funding for a study in microsatellite stable colorectal cancer at the Netherlands Cancer Institute. Both programs are designed to answer the essential question: Can LB-100 unlock the effectiveness of leading immunotherapies where they have historically failed?There are risks, of course. The colorectal study is under a temporary voluntary safety pause following early adverse events, a reminder that novel mechanisms often carry unknowns. Yet Phase 1 data in soft-tissue sarcoma demonstrated LB-100's tolerability with no toxicity concerns. And LIXTE has since discontinued its Phase 2 monotherapy sarcoma program, not as a retreat but as a recalibration. The company is prioritizing immunotherapy combinations where commercial potential is exponentially higher. It is the kind of strategic pruning that signals focus rather than weakness.In oncology, timing matters. LIXTE knows that drug developers win not by stretching themselves thin but by aiming resources where the science is strongest and the market most receptive. That is why LB-100's journey looks less like a straight line and more like a chessboard, with each move setting up the next. Still, the full weight of LIXTE's story is not in the science alone but in how the company prepares to sustain it.Where Science Meets Financial StrategyThis summer, LIXTE caught attention for a move that had little to do with clinical trials. It announced the purchase of a $2.6 million portfolio of digital assets, positioning nearly half of its treasury in this new category. For many observers, it was unexpected. For LIXTE, it was intentional.The company described it as a forward-looking balance sheet strategy designed to create value drivers alongside the science. In an industry where most companies focus exclusively on burning cash, LIXTE is experimenting with how to grow and diversify it. The message was clear: innovation at LIXTE is not confined to the lab. Its treasury can also be an active creator of capital.Pair that with a leadership team reshaped over the past quarter, including a new CFO and new board members with financial and operational expertise, and you start to see a company aligning its corporate strategy with its scientific ambition. A company developing a first-in-class drug is also building a first-in-class approach to how it funds and sustains that drug.And that dual-track innovation may prove to be LIXTE's most defining trait.A Company With Two NarrativesOn one level, LIXTE presents the biotech story everyone wants to see: a unique mechanism validated in Nature, clinical collaborations with global leaders like GSK and Roche, and a shot at redefining standards of care in cancers long resistant to treatment. On another level, it is a corporate story about a company unwilling to accept the limits of traditional playbooks, whether in finance, governance, or growth strategy.In September 2025, those two narratives define LIXTE. Scientifically, it is advancing a one-of-a-kind cancer drug with global validation and partnerships. Strategically, it is reshaping its balance sheet to think differently about value creation. Taken together, LIXTE is showing that real progress comes not from a single dimension but from strength across science, partnerships, and capital.In oncology, where the margin between success and failure can define lives, that breadth of vision may prove to be the company's defining value driver.Sources and references:<ul><li>https://ir.lixte.com/news-events/press-releases/detail/137/lixte-biotechnology-holdings-makes-2-6-million-initial-purchase-of-digital-currency-to-diversify-treasury-and-for-potential-acquisitions</li><li>https://ir.lixte.com/news-events/press-releases/detail/136/lixte-biotechnology-holdings-appoints-two-new-board-members-and-new-chief-financial-officer</li><li>https://ir.lixte.com/news-events/press-releases/detail/133/lixte-biotechnology-holdings-provides-corporate-update</li><li>https://ir.lixte.com/news-events/press-releases/detail/129/lixte-biotechnology-holdings-updates-corporate-treasury-policy-to-include-cryptocurrency</li><li>https://ir.lixte.com/news-events/press-releases/detail/127/new-clinical-findings-published-in-scientific-journal-nature-validate-lixtes-ongoing-ovarian-and-colorectal-cancer-trials</li><li>https://ir.lixte.com/news-events/press-releases/detail/126/lixte-biotechnology-holdings-inc-announces-the-closing-of-1-5-million-registered-direct-offering</li><li>https://ir.lixte.com/news-events/press-releases/detail/124/lixte-biotechnology-holdings-inc-announces-5-0-million-private-placement-priced-at-the-market</li><li>https://ir.lixte.com/</li></ul>Company ProfileLIXTE Biotechnology Holdings, Inc. is a clinical-stage pharmaceutical company developing a new class of cancer therapy called PP2A inhibitors. The Company's innovative approach enhances the efficacy of both chemotherapy and immunotherapy, potentially providing new treatment options for patients. At the core of the Company's therapy is LB-100, the Company's proprietary compound that acts as an inhibitor of the PP2A phosphatase with a favorable toxicity profile. LB-100 promotes the production of neoantigens and cytokines, boosts T-cell proliferation, and disrupts the DNA repair mechanisms of cancer cells, potentially improving treatment outcomes. The Company is conducting multiple clinical trials for solid tumors with unmet medical needs. LIXTE's unique approach has no known competitors and is covered by a comprehensive patent portfolio.Forward-Looking StatementsThis article was prepared by Hawk Point Media Group, LLC and may contain information, views, or opinions regarding the future expectations, plans, and prospects of Lixte Biotechnology Holdings, Inc. that constitute or may constitute forward-looking statements. These statements are not historical facts and are based on assumptions, beliefs, and expectations regarding future economic and operating performance. Although Hawk Point Media Group, LLC believes such statements are made in good faith and based on information available at the time of writing, there can be no assurance that the expectations expressed will prove accurate. Lixte Biotechnology Holdings, Inc. and Hawk Point Media Group, LLC undertake no obligation to update or revise any forward-looking statements, except as required by applicable law.Forward-looking statements are inherently subject to risks, uncertainties, and factors that could cause actual results to differ materially from those projected. Such factors include, but are not limited to, industry conditions, regulatory developments, economic trends, and risks identified in Lixte Biotechnology Holdings, Inc.'s filings with the Securities and Exchange Commission. Readers are cautioned not to place undue reliance on forward-looking statements, which speak only as of the date of publication.Accuracy &amp; Disclosure Statement: Hawk Point Media Group, LLC (HPM) works on a retainer basis with IR Agency, Inc. to provide press release, editorial, digital media, and consulting services. Accordingly, IR Agency, Inc. may engage HPM to create content relating to multiple public companies during the term of its retainer. Up to five thousand dollars of the retainer may be allocated toward the creation and syndication of the content printed above. Because of this arrangement, this content should be considered sponsored content. The information contained herein is based on sources believed to be reliable, including publicly available filings, company disclosures, and direct website content, and is accurate to the best of our knowledge at the time of creation. This content is for informational purposes only and should not be construed as investment advice. At the time of creation, HPM does not own, buy, sell, or trade securities of the companies covered. Any reproduction or syndication of this content must include this statement. This disclosure is made in accordance with Section 17(b) of the Securities Act of 1933, the Federal Trade Commission's Endorsement Guides, and other applicable regulations governing sponsored investment content.Contact:info@hawkpointmedia.comSOURCE: Lixte Biotechnology Holdings, Inc.View the original press release on ACCESS Newswire</div></div>

LIXT

LIXTE Biotechnology Holdings is focusing on its lead compound, LB-100, a unique inhibitor of protein phosphatase 2A (PP2A) that disrupts cancer's survival mechanisms. This approach aims to enhance the effectiveness of existing treatments, particularly for resistant cancers like microsatellite stable colorectal cancer and ovarian clear-cell carcinoma. LIXTE has partnered with GSK and Roche for clinical trials, while also diversifying its financial strategy by investing in digital assets. This dual focus on scientific innovation and financial sustainability positions LIXTE as a forward-thinking biotech company.

LIXTE's Bold Blueprint to Rewire Cancer's Master Switch and Redefine Its Own Future (NASDAQ: LIXT)