NASDAQ Composite Index has fell 0.67%, with a year-to-date rose 18%; S&amp;P 500 has fell 0.38%, with a year-to-date rose 14.2%; Dow Jones Industrial Average has fell 0.2%, with a year-to-date rose 9.5%.Biodexa Pharmaceuticals(BDRX) rose 24.89%, with a trading turnover 1.0 Million USD, and a year-to-date fell 79.6%.
AppLovin(APP) rose 7.64%, with a trading turnover 7.3 Billion USD, and a year-to-date rose 95.1%.
Lam Research(LRCX) fell 5.9%, with a trading turnover 2.4 Billion USD, and a year-to-date rose 95.8%.
Applied Materials(AMAT) fell 5.52%, with a trading turnover 2.3 Billion USD, and a year-to-date rose 31.1%.<img src="https://pub.pbkrs.com/screenshot/us_company_top_five_2025-10-08_en-1759874441165890353.png?x-oss-process=style/lg" original-src="https://pub.pbkrs.com/screenshot/us_company_top_five_2025-10-08_en-1759874441165890353.png"/>

BDRX

DELL

GILD

LRCX

AMAT

KLAC

TSLA

ASML

Biodexa Pharmaceuticals(BDRX) rose 24.89%, with a trading turnover 1.0 Million USD, and a year-to-date fell 79.6%. AppLovin(APP) rose 7.64%, with a trading turnover 7.3 Billion USD, and a year-to-date rose 95.1%. Lam Research(LRCX) fell 5.9%, with a trading turnover 2.4 Billion USD, and a year-to-date rose 95.8%. Applied Materials(AMAT) fell 5.52%, with a trading turnover 2.3 Billion USD, and a year-to-date rose 31.1%.

- The Nasdaq Composite Index fell by 0.67%, with an annual increase of 18%.  
- The S&P 500 Index decreased by 0.38%, up 14.2% year-to-date, while the Dow Jones Index dropped by 0.2%, with a 9.5% annual gain.  
- Biodexa Pharmaceuticals surged by 24.89% despite a 79.6% decline this year, while AppLovin rose by 7.64% with a 95.1% year-to-date increase.  

Top 5 US Stock Gainers/Losers (>100B) (10.7)