<div id="readability-page-1"><div>RNS Number : 8188C PureTech Health PLC 09 October 2025 TR-1: Standard form for notification of major holdings1. Issuer DetailsISINGB00BY2Z0H74Issuer NamePURETECH HEALTH PLCUK or Non-UK IssuerUK2. Reason for NotificationAn acquisition or disposal of voting rights; An acquisition or disposal of financial instruments; OtherCommentsA change in nature of attribution due to an increase in Right to Recall securities and a reduction of voting rights3. Details of person subject to the notification obligationNameCitigroup Inc.City of registered office (if applicable)WILMINGTONCountry of registered office (if applicable)United States of America4. Details of the shareholderFull name of shareholder(s) if different from the person(s) subject to the notification obligation, aboveCity of registered office (if applicable)Country of registered office (if applicable)5. Date on which the threshold was crossed or reached08-Oct-20256. Date on which Issuer notified09-Oct-20257. Total positions of person(s) subject to the notification obligation<div><table><tbody><tr><td></td><td>% of voting rights attached to shares (total of 8.A)</td><td>% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)</td><td>Total of both in % (8.A + 8.B)</td><td>Total number of voting rights held in issuer</td></tr><tr><td>Resulting situation on the date on which threshold was crossed or reached</td><td>4.809764</td><td>0.852061</td><td>5.661825</td><td>13683728</td></tr><tr><td>Position of previous notification (if applicable)</td><td>5.622232</td><td>0.087731</td><td>5.709963</td><td></td></tr></tbody></table></div>8. Notified details of the resulting situation on the date on which the threshold was crossed or reached8A. Voting rights attached to shares<div><table><tbody><tr><td>Class/Type of shares ISIN code(if possible)</td><td>Number of direct voting rights (DTR5.1)</td><td>Number of indirect voting rights (DTR5.2.1)</td><td>% of direct voting rights (DTR5.1)</td><td>% of indirect voting rights (DTR5.2.1)</td></tr><tr><td>GB00BY2Z0H74</td><td>11624432</td><td></td><td>4.809764</td><td></td></tr><tr><td>Sub Total 8.A</td><td colspan="2">11624432</td><td colspan="2">4.809764%</td></tr></tbody></table></div>8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))<div><table><tbody><tr><td>Type of financial instrument</td><td>Expiration date</td><td>Exercise/conversion period</td><td>Number of voting rights that may be acquired if the instrument is exercised/converted</td><td>% of voting rights</td></tr><tr><td>Right to Recall</td><td></td><td></td><td>1892266</td><td>0.782950</td></tr><tr><td>Sub Total 8.B1</td><td colspan="2"></td><td>1892266</td><td>0.782950%</td></tr></tbody></table></div>8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))<div><table><tbody><tr><td>Type of financial instrument</td><td>Expiration date</td><td>Exercise/conversion period</td><td>Physical or cash settlement</td><td>Number of voting rights</td><td>% of voting rights</td></tr><tr><td>OTC swap</td><td>11.09.2026</td><td></td><td>Cash</td><td>167030</td><td>0.069111</td></tr><tr><td>Sub Total 8.B2</td><td colspan="3"></td><td>167030</td><td>0.069111%</td></tr></tbody></table></div>9. Information in relation to the person subject to the notification obligation2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)<div><table><tbody><tr><td>Ultimate controlling person</td><td>Name of controlled undertaking</td><td>% of voting rights if it equals or is higher than the notifiable threshold</td><td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td><td>Total of both if it equals or is higher than the notifiable threshold</td></tr><tr><td>Citigroup Inc.</td><td></td><td></td><td></td><td></td></tr><tr><td>Citigroup Inc.</td><td>Citigroup Global Markets Holdings Inc.</td><td></td><td></td><td></td></tr><tr><td>Citigroup Inc.</td><td>Citigroup Financial Products Inc.</td><td></td><td></td><td></td></tr><tr><td>Citigroup Inc.</td><td>Citigroup Global Markets Holdings Bahamas Limited</td><td></td><td></td><td></td></tr><tr><td>Citigroup Inc.</td><td>Citigroup Global Markets Limited</td><td></td><td></td><td>5.661825%</td></tr></tbody></table></div>10. In case of proxy votingName of the proxy holderThe number and % of voting rights heldThe date until which the voting rights will be held11. Additional Information12. Date of Completion09-Oct-202513. Place Of CompletionBelfastThis information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy. 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PRTC

Citigroup Inc. has notified PureTech Health PLC of a change in its voting rights, following an acquisition and disposal of financial instruments. As of October 8, 2025, Citigroup holds 4.81% of voting rights attached to shares and 0.85% through financial instruments, totaling 5.66%. This marks a decrease from the previous holding of 5.71%. The notification was completed on October 9, 2025, and is part of regulatory compliance under UK law.

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