NASDAQ Composite Index has fell 0.08%, with a year-to-date rose 19.2%; S&amp;P 500 has fell 0.28%, with a year-to-date rose 14.5%; Dow Jones Industrial Average has fell 0.52%, with a year-to-date rose 9%.Biodexa Pharmaceuticals(BDRX) rose 41.37%, with a trading turnover 64.2 Million USD, and a year-to-date fell 73.1%.
Mercadolibre(MELI) rose 4.36%, with a trading turnover 1.2 Billion USD, and a year-to-date rose 33.8%.
HSBC(HSBC) fell 5.83%, with a trading turnover 221.4 Million USD, and a year-to-date rose 42.7%.
Dell Tech(DELL) fell 5.21%, with a trading turnover 2.1 Billion USD, and a year-to-date rose 37.3%.<img src="https://pub.pbkrs.com/screenshot/us_company_top_five_2025-10-10_en-1760047231121185041.png?x-oss-process=style/lg" original-src="https://pub.pbkrs.com/screenshot/us_company_top_five_2025-10-10_en-1760047231121185041.png"/>

BDRX

MELI

COST

HSBC

DELL

BABA

Biodexa Pharmaceuticals(BDRX) rose 41.37%, with a trading turnover 64.2 Million USD, and a year-to-date fell 73.1%. Mercadolibre(MELI) rose 4.36%, with a trading turnover 1.2 Billion USD, and a year-to-date rose 33.8%. HSBC(HSBC) fell 5.83%, with a trading turnover 221.4 Million USD, and a year-to-date rose 42.7%. Dell Tech(DELL) fell 5.21%, with a trading turnover 2.1 Billion USD, and a year-to-date rose 37.3%.

- The Nasdaq Composite Index fell by 0.08%, with a year-to-date increase of 19.2%.  
- Biodexa Pharmaceuticals (BDRX) surged by 41.37% despite a year-to-date decline of 73.1%, while Latin American e-commerce firm Mercado Libre (MELI) rose by 4.36% with a 33.8% year-to-date gain.  
- HSBC and Dell Technologies (DELL) experienced declines of 5.83% and 5.21%, respectively, with year-to-date increases of 42.7% and 37.3%.  

Top 5 US Stock Gainers/Losers (>100B) (10.9)