NASDAQ Composite Index has rose 0.52%, with a year-to-date rose 17.4%; S&amp;P 500 has rose 0.53%, with a year-to-date rose 13.3%; Dow Jones Industrial Average has rose 0.52%, with a year-to-date rose 8.6%.American Express(AXP) rose 7.27%, with a trading turnover 2.4 Billion USD, and a year-to-date rose 18%.
Gilead Sciences(GILD) rose 4.21%, with a trading turnover 1.9 Billion USD, and a year-to-date rose 35.8%.
Oracle(ORCL) fell 6.93%, with a trading turnover 11.0 Billion USD, and a year-to-date rose 76.5%.
Biodexa Pharmaceuticals(BDRX) fell 6.83%, with a trading turnover 174.5 Thousand USD, and a year-to-date fell 80.8%.<img src="https://pub.pbkrs.com/screenshot/us_company_top_five_2025-10-18_en-1760738440939354985.png?x-oss-process=style/lg" original-src="https://pub.pbkrs.com/screenshot/us_company_top_five_2025-10-18_en-1760738440939354985.png"/>

GILD

ORCL

BDRX

IBKR

American Express(AXP) rose 7.27%, with a trading turnover 2.4 Billion USD, and a year-to-date rose 18%. Gilead Sciences(GILD) rose 4.21%, with a trading turnover 1.9 Billion USD, and a year-to-date rose 35.8%. Oracle(ORCL) fell 6.93%, with a trading turnover 11.0 Billion USD, and a year-to-date rose 76.5%. Biodexa Pharmaceuticals(BDRX) fell 6.83%, with a trading turnover 174.5 Thousand USD, and a year-to-date fell 80.8%.

- The Nasdaq Composite Index rose by 0.52%, with a year-to-date increase of 17.4%.  
- The S&P 500 Index increased by 0.53%, accumulating a 13.3% rise this year, while the Dow Jones Index also gained 0.52%, up 8.6% year-to-date.  
- Notable stock movements include American Express rising 7.27% and Gilead Sciences increasing 4.21%, while Oracle fell 6.93% and Biodexa Pharmaceuticals dropped 6.83%.

Top 5 US Stock Gainers/Losers (>100B) (10.17)