<div id="readability-page-1"><div>RNS Number : 3333J Renalytix PLC 27 November 2025 TR-1: Standard form for notification of major holdings<div><table><tbody><tr><td colspan="7">NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and to the FCA in Microsoft Word format if possible) i</td></tr><tr><td colspan="7"></td></tr><tr><td colspan="3">1a. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached ii:</td><td colspan="4">Renalytix PLCGB00BYWL4Y04</td></tr><tr><td colspan="7">1b. Please indicate if the issuer is a non-UK issuer (please mark with an &#34;X&#34; if appropriate)</td></tr><tr><td colspan="6"></td><td></td></tr><tr><td colspan="7">2. Reason for the notification (please mark the appropriate box or boxes with an &#34;X&#34;)</td></tr><tr><td colspan="6">An acquisition or disposal of voting rights</td><td>X</td></tr><tr><td colspan="6">An acquisition or disposal of financial instruments</td><td></td></tr><tr><td colspan="6">An event changing the breakdown of voting rights</td><td></td></tr><tr><td colspan="6">Other (please specify) iii:</td><td></td></tr><tr><td colspan="7">3. Details of person subject to the notification obligation iv</td></tr><tr><td colspan="3">Name</td><td colspan="4">UBS Group AG - Investment Bank &amp; Global Wealth Management</td></tr><tr><td colspan="3">City and country of registered office (if applicable)</td><td colspan="4">ZürichSwitzerland</td></tr><tr><td colspan="7">4. Full name of shareholder(s) (if different from 3.) v</td></tr><tr><td colspan="3">Name</td><td colspan="4">UBS AG</td></tr><tr><td colspan="3">City and country of registered office (if applicable)</td><td colspan="4">London, United Kingdom</td></tr><tr><td colspan="3">5. Date on which the threshold was crossed or reached vi:</td><td colspan="4">25 November 2025</td></tr><tr><td colspan="3">6. Date on which issuer notified (DD/MM/YYYY):</td><td colspan="4">27 November 2025</td></tr><tr><td colspan="7">7. Total positions of person(s) subject to the notification obligation</td></tr><tr><td></td><td>% of voting rights attached to shares (total of 8. A)</td><td colspan="2">% of voting rights through financial instruments(total of 8.B 1 + 8.B 2)</td><td>Total of both in % (8.A + 8.B)</td><td colspan="2">Total number of voting rights held in issuer (8.A + 8.B) vii</td></tr><tr><td>Resulting situation on the date on which threshold was crossed or reached</td><td>5.089787%</td><td colspan="2"> 0.000000%</td><td>5.089787%</td><td colspan="2">22,243,319</td></tr><tr><td>Position of previous notification (ifapplicable)</td><td>0.000000%</td><td colspan="2"> 0.000000%</td><td> 0.000000%</td><td colspan="2"></td></tr></tbody></table></div><div><table><tbody><tr><td colspan="10">8. Notified details of the resulting situation on the date on which the threshold was crossed or reached viii</td></tr><tr><td colspan="10">A: Voting rights attached to shares</td></tr><tr><td colspan="2" rowspan="2">Class/type ofsharesISIN code (if possible)</td><td colspan="5">Number of voting rights ix</td><td colspan="3">% of voting rights</td></tr><tr><td colspan="2">Direct(DTR5.1)</td><td colspan="3">Indirect (DTR5.2.1)</td><td colspan="2">Direct(DTR5.1)</td><td>Indirect(DTR5.2.1)</td></tr><tr><td colspan="2">GB00BYWL4Y04</td><td colspan="2"></td><td colspan="3">22,243,319</td><td colspan="2"></td><td>5.089787%</td></tr><tr><td colspan="2"></td><td colspan="2"></td><td colspan="3"></td><td colspan="2"></td><td></td></tr><tr><td colspan="2"></td><td colspan="2"></td><td colspan="3"></td><td colspan="2"></td><td></td></tr><tr><td colspan="2">SUBTOTAL 8. A</td><td colspan="5">22,243,319</td><td colspan="3">5.089787%</td></tr><tr><td colspan="10"></td></tr><tr><td colspan="10">B 1: Financial Instruments according to DTR5.3.1R (1) (a)</td></tr><tr><td colspan="2">Type of financial instrument</td><td>Expirationdate x</td><td colspan="3">Exercise/Conversion Period xi</td><td colspan="3">Number of voting rights that may be acquired if the instrument isexercised/converted.</td><td>% of voting rights</td></tr><tr><td colspan="2"></td><td></td><td colspan="3"></td><td colspan="3"></td><td></td></tr><tr><td colspan="2"></td><td></td><td colspan="3"></td><td colspan="3"></td><td></td></tr><tr><td colspan="2"></td><td></td><td colspan="3"></td><td colspan="3"></td><td></td></tr><tr><td colspan="2"></td><td></td><td colspan="3">SUBTOTAL 8. B 1</td><td colspan="3"></td><td></td></tr><tr><td colspan="10"></td></tr><tr><td colspan="10">B 2: Financial Instruments with similar economic effect according to DTR5.3.1R (1) (b)</td></tr><tr><td>Type of financial instrument</td><td colspan="2">Expirationdate x</td><td colspan="2">Exercise/Conversion Period xi</td><td colspan="3">Physical or cashSettlement xii</td><td>Number of voting rights</td><td>% of voting rights</td></tr><tr><td></td><td colspan="2"></td><td colspan="2"></td><td colspan="3"></td><td></td><td></td></tr><tr><td></td><td colspan="2"></td><td colspan="2"></td><td colspan="3"></td><td></td><td></td></tr><tr><td></td><td colspan="2"></td><td colspan="2"></td><td colspan="3"></td><td></td><td></td></tr><tr><td></td><td colspan="2"></td><td colspan="2"></td><td colspan="3">SUBTOTAL 8.B.2</td><td></td><td></td></tr><tr><td colspan="10"></td></tr></tbody></table></div><div><table><tbody><tr><td colspan="5">9. Information in relation to the person subject to the notification obligation (please mark theapplicable box with an &#34;X&#34;)</td></tr><tr><td colspan="4">Person subject to the notification obligation is not controlled by any natural person or legal entity and does not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer xiii</td><td></td></tr><tr><td colspan="4">Full chain of controlled undertakings through which the voting rights and/or thefinancial instruments are effectively held starting with the ultimate controlling natural person or legal entity (please add additional rows as necessary) xiv</td><td>X</td></tr><tr><td>Name xv</td><td>% of voting rights if it equals or is higher than the notifiable threshold</td><td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td><td colspan="2">Total of both if it equals or is higher than the notifiable threshold</td></tr><tr><td>UBS Group AG</td><td></td><td></td><td colspan="2"></td></tr><tr><td>UBS AG</td><td>5.089787%</td><td></td><td colspan="2">5.089787%</td></tr><tr><td colspan="5"></td></tr><tr><td colspan="5">10. In case of proxy voting, please identify:</td></tr><tr><td colspan="2">Name of the proxy holder</td><td colspan="3"></td></tr><tr><td colspan="2">The number and % of voting rights held</td><td colspan="3"></td></tr><tr><td colspan="2">The date until which the voting rights will be held</td><td colspan="3"></td></tr><tr><td colspan="5"></td></tr><tr><td colspan="5">11. Additional information xvi</td></tr><tr><td colspan="5"></td></tr></tbody></table></div><div><table><tbody><tr><td>Place of completion</td><td>Zurich, Switzerland</td></tr><tr><td>Date of completion</td><td>27.11.2025</td></tr></tbody></table></div>This information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy. END HOLFLFVSLDLDFIE</div></div>

RNLXY

RNLXD

Renalytix PLC has received a notification of major holdings from UBS Group AG, indicating a change in voting rights due to an acquisition or disposal. UBS now holds 5.089787% of voting rights in Renalytix PLC, totaling 22,243,319 shares. The notification was completed in Zurich, Switzerland, on 27 November 2025.

REG - Renalytix PLC - Holding(s) in Company