<div id="readability-page-1"><div><ul> <li>Ionis Pharmaceuticals recently received a positive opinion from the European Medicines Agency’s Committee for Donidalorsen, a drug for hereditary angioedema, with a final regulatory decision expected in early 2026, and also announced plans to raise US$700 million through Convertible Senior Notes due 2030.</li> <li>Recent insider transactions, including major share sales and option exercises by executives and directors, occurred alongside these regulatory and corporate financing developments.</li> <li>We’ll explore how European regulatory momentum for Donidalorsen may reshape Ionis Pharmaceuticals' outlook and future growth narrative.</li> </ul><p>We've found 15 US stocks that are forecast to pay a dividend yield of over 6% next year. See the full list for free.</p><h2>Ionis Pharmaceuticals Investment Narrative Recap</h2><p>To be a shareholder of Ionis Pharmaceuticals, you need to believe in the company’s ability to bring its RNA-targeted therapies to global markets, especially as late-stage product launches like Donidalorsen advance toward commercialization. The recent positive regulatory opinion for Donidalorsen in Europe represents a crucial short-term catalyst; however, these developments do not materially alter the near-term risk of regulatory or execution setbacks for its core late-stage programs, which remain the most significant challenges ahead.</p> <p>The announcement that Ionis plans to raise US$700 million through Convertible Senior Notes due 2030 is particularly relevant, as it strengthens the company’s cash reserves to support commercial launches and late-stage trials. This capital infusion could help buffer the company during any delays or challenges in bringing its lead assets to market, aligning with the timing of regulatory milestones for Donidalorsen and Olezarsen.</p> <p>Yet, in contrast, investors should be aware that Ionis’s reliance on successful regulatory outcomes for a few late-stage drugs could...</p> <p>Read the full narrative on Ionis Pharmaceuticals (it's free!)</p><p>Ionis Pharmaceuticals is projected to reach $1.5 billion in revenue and $241.3 million in earnings by 2028. This outlook assumes annual revenue growth of 16.7% and an earnings increase of $509.5 million from current earnings of -$268.2 million.</p><p>Uncover how Ionis Pharmaceuticals' forecasts yield a $85.47 fair value, a 3% upside to its current price.</p><h2>Exploring Other Perspectives</h2><figure><img height="476" src="https://imageproxy.pbkrs.com/https://images.simplywall.st/company/7a2d2500-f224-4ede-8980-f4a13ac5a676/chart/community-fair-value?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="746" original-src="https://imageproxy.pbkrs.com/https://images.simplywall.st/company/7a2d2500-f224-4ede-8980-f4a13ac5a676/chart/community-fair-value"/><figcaption>IONS Community Fair Values as at Nov 2025</figcaption></figure> <p>Four fair value estimates from the Simply Wall St Community for Ionis Pharmaceuticals range from US$36.19 to US$220.97 per share. While price targets vary widely, recent regulatory milestones for Donidalorsen highlight how swiftly approval risk can impact future expectations around the company’s growth and returns.</p><p>Explore 4 other fair value estimates on Ionis Pharmaceuticals - why the stock might be worth less than half the current price!</p><h2>Build Your Own Ionis Pharmaceuticals Narrative</h2><p>Disagree with existing narratives? Create your own in under 3 minutes - extraordinary investment returns rarely come from following the herd.</p><ul><li>A great starting point for your Ionis Pharmaceuticals research is our analysis highlighting 2 key rewards that could impact your investment decision.</li><li>Our free Ionis Pharmaceuticals research report provides a comprehensive fundamental analysis summarized in a single visual - the Snowflake - making it easy to evaluate Ionis Pharmaceuticals' overall financial health at a glance.</li></ul><h2>Curious About Other Options?</h2><p>Markets shift fast. These stocks won't stay hidden for long. Get the list while it matters:</p><ul><li>Uncover the next big thing with financially sound penny stocks that balance risk and reward.</li><li>The best AI stocks today may lie beyond giants like Nvidia and Microsoft. Find the next big opportunity with these 25 smaller AI-focused companies with strong growth potential through early-stage innovation in machine learning, automation, and data intelligence that could fund your retirement.</li><li>AI is about to change healthcare. These 30 stocks are working on everything from early diagnostics to drug discovery. The best part - they are all under $10b in market cap - there's still time to get in early.</li></ul> <p><em> This article by Simply Wall St is general in nature. <strong>We provide commentary based on historical data     and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice.</strong> It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your     financial situation. We aim to bring you long-term focused analysis driven by fundamental data.     Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material.     Simply Wall St has no position in any stocks mentioned.</em></p></div></div>

IONS

<p>Ionis Pharmaceuticals' stock rose 8.7% following a positive opinion from the European Medicines Agency for Donidalorsen, a drug for hereditary angioedema, with a final decision expected in early 2026. The company also announced plans to raise $700 million through Convertible Senior Notes due 2030. These developments are seen as crucial for the company's future growth and financial stability.</p>

Why Ionis Pharmaceuticals (IONS) Is Up 8.7% After Donidalorsen EMA Milestone and $700 Million Offering News