<div id="readability-page-1"><div>Tabuteau Herriot Chairman of the Board of Axsome Therapeutics Inc [AXSM] filed a Form 4 on December 4, 2025 with the Securities and Exchange Commission disclosing the following changes in ownership:<div><table><tbody><tr><th>Date</th><th>Transaction</th><th>Shares</th><th>Price</th><th>Value</th></tr><tr><td>12/2/25-12/4/25</td><td>Planned Exercise(1)</td><td>79,973</td><td>$8.02</td><td>$641,383</td></tr><tr><td>12/2/25-12/4/25</td><td>Planned Sale(1)</td><td>79,973</td><td>$145.66</td><td>$11,648,579</td></tr></tbody></table></div>Ending Holdings: 7,351,729 (7,229 - Direct, 7,344,500 - Indirect)<ul><li>(1)</li><li>Executed pursuant to a prearranged trading plan (10b5-1).</li></ul>For a free trial, or to learn more about our insider trading analysis and data services, please visit http://www.washingtonservice.com or contact us at (301) 913-5100 or send an email to info@washingtonservice.com.Founded in 1970, The Washington Service provides securities professionals with financial, economic and public policy research and data. </div></div>

AXSM

Tabuteau Herriot, Chairman of Axsome Therapeutics Inc, sold 79,973 shares worth $11.6M, as disclosed in a Form 4 filed with the SEC. The transaction was executed under a prearranged trading plan (10b5-1). Ending holdings are 7,351,729 shares. The Washington Service offers insider trading analysis and data services.

Chmn Tabuteau Sells 79,973 ($11.6M) Of Axsome Therapeutics Inc [AXSM]