<div id="readability-page-1"><div>RNS Number : 6849K Hemogenyx Pharmaceuticals PLC 08 December 2025 TR-1: Standard form for notification of major holdings1. Issuer DetailsISINGB00BQVXM815Issuer NameHEMOGENYX PHARMACEUTICALS PLCUK or Non-UK IssuerUK2. Reason for NotificationAn acquisition or disposal of voting rights3. Details of person subject to the notification obligationNameDavid John SmithCity of registered office (if applicable)grimsbyCountry of registered office (if applicable)United Kingdom4. Details of the shareholder<div><table><tbody><tr><td>Name</td><td>City of registered office</td><td>Country of registered office</td></tr><tr><td>GHC Property Services Limited</td><td>Grimsby</td><td>England</td></tr><tr><td>Copier Systems Limited</td><td>Scunthorpe</td><td>England</td></tr><tr><td>HBP Monpellier Limited</td><td>Carlisle</td><td>England</td></tr><tr><td>Kamarin Computers Limited</td><td>Scunthorpe</td><td>England</td></tr><tr><td>HBP Systems Limited</td><td>Scunthorpe</td><td>England</td></tr><tr><td>Transact Nominees Limited</td><td>London</td><td>England</td></tr><tr><td>Interactive Investor Services Nominees Limited</td><td>Manchester</td><td>England</td></tr></tbody></table></div>5. Date on which the threshold was crossed or reached24-Nov-20256. Date on which Issuer notified24-Nov-20257. Total positions of person(s) subject to the notification obligation<div><table><tbody><tr><td></td><td>% of voting rights attached to shares (total of 8.A)</td><td>% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)</td><td>Total of both in % (8.A + 8.B)</td><td>Total number of voting rights held in issuer</td></tr><tr><td>Resulting situation on the date on which threshold was crossed or reached</td><td>6.750640</td><td>0.000000</td><td>6.750640</td><td>399478</td></tr><tr><td>Position of previous notification (if applicable)</td><td>5.163200</td><td>0.000000</td><td>5.163200</td><td></td></tr></tbody></table></div>8. Notified details of the resulting situation on the date on which the threshold was crossed or reached8A. Voting rights attached to shares<div><table><tbody><tr><td>Class/Type of shares ISIN code(if possible)</td><td>Number of direct voting rights (DTR5.1)</td><td>Number of indirect voting rights (DTR5.2.1)</td><td>% of direct voting rights (DTR5.1)</td><td>% of indirect voting rights (DTR5.2.1)</td></tr><tr><td>GB00BQVXM815</td><td>211976</td><td>187502</td><td>3.582000</td><td>3.168640</td></tr><tr><td>Sub Total 8.A</td><td colspan="2">399478</td><td colspan="2">6.750640%</td></tr></tbody></table></div>8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))<div><table><tbody><tr><td>Type of financial instrument</td><td>Sub Total 8.B1</td></tr><tr><td>Expiration date</td><td colspan="2"></td></tr><tr><td>Exercise/conversion period</td><td></td></tr><tr><td>Number of voting rights that may be acquired if the instrument is exercised/converted</td><td></td></tr><tr><td>% of voting rights</td></tr></tbody></table></div>8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))<div><table><tbody><tr><td>Type of financial instrument</td><td>Sub Total 8.B2</td></tr><tr><td>Expiration date</td><td colspan="3"></td></tr><tr><td>Exercise/conversion period</td><td></td></tr><tr><td>Physical or cash settlement</td><td></td></tr><tr><td>Number of voting rights</td></tr><tr><td>% of voting rights</td></tr></tbody></table></div>9. Information in relation to the person subject to the notification obligation2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)<div><table><tbody><tr><td>Ultimate controlling person</td><td>Name of controlled undertaking</td><td>% of voting rights if it equals or is higher than the notifiable threshold</td><td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td><td>Total of both if it equals or is higher than the notifiable threshold</td></tr><tr><td>David Smith</td><td></td><td>6.750360</td><td></td><td>6.750360%</td></tr><tr><td>David Smith</td><td>GHC Property Services Limited</td><td>2.464300</td><td></td><td>2.464300%</td></tr><tr><td>David Smith</td><td>HBP Systems Limited</td><td>0.275400</td><td></td><td>0.275400%</td></tr><tr><td>David Smith</td><td>Kamarin Computers Limited</td><td>0.275400</td><td></td><td>0.275400%</td></tr><tr><td>David Smith</td><td>HBP Monpellier Limited</td><td>0.275400</td><td></td><td>0.275400%</td></tr><tr><td>David Smith</td><td>Copier Systems Limited</td><td>0.275400</td><td></td><td>0.275400%</td></tr></tbody></table></div>10. In case of proxy votingName of the proxy holderThe number and % of voting rights heldThe date until which the voting rights will be held11. Additional InformationCorrection of a previous notification12. Date of Completion05-Dec-202513. Place Of CompletionHull, EnglandThis information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. 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Hemogenyx Pharmaceuticals PLC has announced a change in major holdings. David John Smith has increased his voting rights to 6.750640% from a previous 5.163200%. The notification was made following an acquisition or disposal of voting rights, with the threshold crossed on November 24, 2025. The notification includes details of various controlled undertakings and their respective voting rights percentages.

REG - Hemogenyx Pharma Plc - Holding(s) in Company