<div id="readability-page-1"><article>Strategic Partnerships Add Exclusivity in Leading EHR, e-Prescription, and Technology Companies, Increasing NPI Reach by 37%WALTHAM, Mass., Dec. 17, 2025 (GLOBE NEWSWIRE) -- OptimizeRx Corp. (the “Company”) (Nasdaq: OPRX), a leading provider of healthcare technology solutions helping life sciences companies reach and engage healthcare professionals (HCPs) and patients, today announced four new partner agreements that meaningfully expand the Company’s in-workflow point-of-care (POC) network, fortify its long-term competitive position, and increase total National Provider Identifier (NPI) reach. The newly executed agreements include: <ul type="disc"><li>An exclusive, multi-year agreement with a high-demand e-prescribing (eRx) platform previously available only through a competitive network</li><li>A new partnership that extends the Company’s presence into the point-of-discharge setting</li><li>Multi-year renewals with two of the Company’s highest-performing electronic health record (EHR) and eRx partners—one of which establishes an exclusive partnership</li></ul> Together, these agreements significantly expand OptimizeRx’s strategic footprint and reinforce the Company’s leadership in the POC marketing landscape. With the addition of two new channel partners, OptimizeRx increases its unique NPI reach by 37%. The new partners include an eRx platform that was previously part of a competitive network, and a health systems access partner that reaches HCPs when treatment plans and patient instructions are finalized. The latter partner also provides OptimizeRx with reach into an extended network of EHR platforms, broadening OptimizeRx clients’ access to healthcare providers directly in the clinical workflow. The renewals strengthen our partnerships with long-term, top-performing EHR and eRx platforms and secure exclusive access to premium inventory. They also increase visibility into future channel revenue, based on the partners’ historical track record of strong utilization, consistent performance, and high ROIs for life sciences brands. “By deepening relationships with proven, high-value partners and adding exclusive access to large-scale platforms that were previously outside our network, we continue to position the Company for sustained, profitable growth, driven by our clients’ ability to reach a larger audience of relevant providers,” said Steve Silvestro, Chief Executive Officer, OptimizeRx. “Life sciences manufacturers continue to recognize the value of in-workflow engagement for driving brand awareness and conversion. Our network scale, technology assets, and strategic partnerships place us in a strong position to capture growing demand and deliver measurable results for our clients. We believe the steps we are taking today will meaningfully enhance the value we deliver to our clients.” About OptimizeRx OptimizeRx is a leading healthcare technology company that’s redefining how life sciences brands connect with patients and healthcare providers. Our platform combines innovative, AI-driven tools like the Dynamic Audience Activation Platform (DAAP) and Micro-Neighborhood® Targeting (MNT) to deliver timely, relevant, and hyper-local engagement. By bridging the gap between HCP and DTC strategies, we empower brands to create synchronized marketing solutions that drive faster treatment decisions and improved patient outcomes. Our commitment to privacy-safe, patient-centric technology ensures that every interaction is designed to make a meaningful impact, delivering life-changing therapies to the right patients at the right time. Headquartered in Waltham, Massachusetts, OptimizeRx partners with some of the world’s leading pharmaceutical and life sciences companies to transform the healthcare landscape and create a healthier future for all. For more information, follow the Company on LinkedIn or X, or visit www.optimizerx.com. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as &#34;expected&#34;, &#34;will&#34;, &#34;believe&#34;, &#34;could&#34;, &#34;may&#34;, &#34;should&#34; or other similar words and expressions are intended to identify these forward-looking statements. All statements in this press release that reflect the Company's expectations, assumptions, projections, beliefs or opinions about the future, other than statements of historical fact, are forward-looking statements, including, without limitation, statements relating to expanding OptimizeRx’s strategic footprint and reinforcing the Company’s leadership in the POC marketing landscape, securing or maintaining exclusive access to premium inventory, increasing visibility into future channel revenue, positioning OptimizeRx for sustained, profitable growth, increasing clients’ ability to reach a greater portion of relevant HCPs, driving brand awareness and conversion, and capturing growing demand and delivering measurable results for clients. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon the Company’s current expectations and involve assumptions regarding the Company's business, the economy, and other future conditions that may never materialize or may prove to be incorrect. Forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted, or quantified. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties including, but not limited to the effect of government regulation, seasonal trends, dependence on a concentrated group of customers, cybersecurity incidents that could disrupt operations, the ability to keep pace with growing and evolving technology, the ability to maintain contracts with eRx platforms and EHR networks, competition, and other factors discussed in the Company’s Annual Report on Form 10-K for the year ended December 31, 2024, and in other filings the Company has made and may make with the SEC in the future. One should not place undue reliance on these forward-looking statements, which speak only as of the date on which they were made. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as may be required by law. OptimizeRx Contact Jennifer Dinkel, VP Marketing jdinkel@optimizerx.com Press Inquiries Matter Communications optimizerx@matternow.com <img src="https://imageproxy.pbkrs.com/https://www.globenewswire.com/newsroom/ti/query-bmY9T1RZd016RTFOeU0zTXpJME9EUTBJekl3TkRrNE9EUT0?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="1" height="1" original-src="https://imageproxy.pbkrs.com/https://www.globenewswire.com/newsroom/ti/query-bmY9T1RZd016RTFOeU0zTXpJME9EUTBJekl3TkRrNE9EUT0"/> <img src="https://imageproxy.pbkrs.com/https://ml.globenewswire.com/media/MjJjOTA4YTItNzg4Ni00OTc3LTk0YWItZWIyMmY2MTZjOTNmLTEwNjE0NTUtMjAyNS0xMi0xNy1lbg==/tiny/OptimizeRx-Corporation.png?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="1" height="1" original-src="https://imageproxy.pbkrs.com/https://ml.globenewswire.com/media/MjJjOTA4YTItNzg4Ni00OTc3LTk0YWItZWIyMmY2MTZjOTNmLTEwNjE0NTUtMjAyNS0xMi0xNy1lbg==/tiny/OptimizeRx-Corporation.png"/></article></div>

OPRX

OptimizeRx Corp. has announced four new strategic partnerships, expanding its point-of-care network and increasing its National Provider Identifier reach by 37%. These agreements include exclusive multi-year deals with e-prescribing platforms and renewals with top-performing EHR partners. The expansion strengthens OptimizeRx's competitive position and enhances its ability to deliver measurable results for life sciences brands. The company aims for sustained growth by increasing its reach to healthcare providers and driving brand awareness.

OptimizeRx Continues Expansion of the Company’s Point-Of-Care Network | OPRX Stock News