Major Investor Quietly Boosts Stake in Sol-Gel Technologies

New insider activity at Sol-Gel Technologies ( (SLGL) ) has taken place on December 19, 2025.Claim 50% Off TipRanks Premium and Invest with Confidence Unlock hedge-fund level data and powerful investing tools designed to help you make smarter, sharper decisions Stay ahead of the market with the latest news and analysis so your portfolio is always positioned for maximum potential Significant shareholder Opaleye Management Inc. has increased its stake in Sol-Gel Technologies by purchasing 2,735 shares of the company’s stock, in a transaction valued at $110,411. This move highlights continued institutional interest in Sol-Gel Technologies and signals confidence in the company’s future performance. Recent Updates on SLGL stock Over the last 24 hours, news on Sol-Gel Technologies has centered on a negative clinical outcome for SGT-210 and a strategic refocus of the pipeline, alongside ongoing concerns about financial performance. The company reported that its Phase 1b proof-of-concept trial of SGT-210 in Darier disease failed to show efficacy versus vehicle, leading management to halt development in that indication and redirect resources toward small, low-cost feasibility studies where the mechanistic rationale is stronger. At the same time, Sol-Gel is emphasizing its late-stage asset SGT-610 for Gorlin syndrome, highlighting the ongoing Phase 3 program and the potential to expand into high-frequency basal cell carcinoma, which could materially increase the drug’s commercial opportunity and help justify a more optimistic long-term outlook. Analysts’ recent price-target work, while not quoted explicitly, appears driven by this shift toward a more focused rare-disease strategy, the enlarged addressable market for SGT-610, and progress in geographic expansion and partnerships for approved products like EPSOLAY, offset by weak current fundamentals such as a sharp year-over-year revenue decline, persistent net losses, negative cash flow, and limited earnings guidance. These mixed signals—pipeline reprioritization and expanded indications on one side, and deteriorated near-term financials and uncertainty on the other—underpin both recent volatility in SLGL trading and the nuanced stance of research and AI-driven assessments that see upside potential but call out the need for clearer financial visibility and execution on late-stage trials. Spark’s Take on SLGL Stock According to Spark, TipRanks’ AI Analyst, SLGL is a Neutral. Sol-Gel Technologies’ stock score reflects significant financial performance challenges due to negative profitability and cash flow issues. Positive technical indicators offer some short-term optimism, but the lack of valuation appeal and guidance from earnings calls creates uncertainty. Strategic financial improvements and clearer future guidance would be needed to enhance the stock’s attractiveness. To see Spark’s full report on SLGL stock, click here. More about Sol-Gel Technologies YTD Price Performance: 359.68% Average Trading Volume: 16,192 Technical Sentiment Signal: Buy Current Market Cap: $114.6M