
LLY, JNJ, PFE: Big Pharma's 2025 Comeback Is Bigger Than the Obesity Craze

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In 2025, Big Pharma's performance was highlighted by the obesity-drug market, but overall gains were driven by broader factors. The NYSE Arca Pharmaceutical Index rose 21%, outperforming the S&P 500's 17.9% gain. Key indices like the Dow Jones U.S. Pharmaceuticals Index and S&P Pharmaceuticals Select Industry Index saw increases of 31% and 30%, respectively. Johnson & Johnson led the growth with a 43% stock increase, followed by Novartis and AstraZeneca, each over 40%. Eli Lilly also performed well, ending the year 39% stronger and entering the $1-trillion club.
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