<div id="readability-page-1"><div>RNS Number : 1218P Life Science REIT PLC 15 January 2026 TR-1: Standard form for notification of major holdings1. Issuer DetailsISINGB00BP5X4Q29Issuer NameLIFE SCIENCE REIT PLCUK or Non-UK IssuerUK2. Reason for NotificationAn acquisition or disposal of voting rights; An acquisition or disposal of financial instruments3. Details of person subject to the notification obligationNameJefferies Financial Group IncCity of registered office (if applicable)Country of registered office (if applicable)US4. Details of the shareholderFull name of shareholder(s) if different from the person(s) subject to the notification obligation, aboveCity of registered office (if applicable)Country of registered office (if applicable)5. Date on which the threshold was crossed or reached14-Jan-20266. Date on which Issuer notified15-Jan-20267. Total positions of person(s) subject to the notification obligation<div><table><tbody><tr><td></td><td>% of voting rights attached to shares (total of 8.A)</td><td>% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)</td><td>Total of both in % (8.A + 8.B)</td><td>Total number of voting rights held in issuer</td></tr><tr><td>Resulting situation on the date on which threshold was crossed or reached</td><td>1.029000</td><td>5.413000</td><td>6.442000</td><td>22546052</td></tr><tr><td>Position of previous notification (if applicable)</td><td>0.000000</td><td>6.445000</td><td>6.445000</td><td></td></tr></tbody></table></div>8. Notified details of the resulting situation on the date on which the threshold was crossed or reached8A. Voting rights attached to shares<div><table><tbody><tr><td>Class/Type of shares ISIN code(if possible)</td><td>Number of direct voting rights (DTR5.1)</td><td>Number of indirect voting rights (DTR5.2.1)</td><td>% of direct voting rights (DTR5.1)</td><td>% of indirect voting rights (DTR5.2.1)</td></tr><tr><td>GB00BP5X4Q29</td><td></td><td>3600101</td><td></td><td>1.029000</td></tr><tr><td>Sub Total 8.A</td><td colspan="2">3600101</td><td colspan="2">1.029000%</td></tr></tbody></table></div>8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))<div><table><tbody><tr><td>Type of financial instrument</td><td>Expiration date</td><td>Exercise/conversion period</td><td>Number of voting rights that may be acquired if the instrument is exercised/converted</td><td>% of voting rights</td></tr><tr><td>stock loan/ repo right of recall</td><td>Open</td><td></td><td>6217831</td><td>1.777000</td></tr><tr><td>Sub Total 8.B1</td><td colspan="2"></td><td>6217831</td><td>1.777000%</td></tr></tbody></table></div>8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))<div><table><tbody><tr><td>Type of financial instrument</td><td>Expiration date</td><td>Exercise/conversion period</td><td>Physical or cash settlement</td><td>Number of voting rights</td><td>% of voting rights</td></tr><tr><td>Swap</td><td>23/12/2026</td><td></td><td>Cash</td><td>3728120</td><td>1.065000</td></tr><tr><td>Swap</td><td>23/12/2026</td><td></td><td>Cash</td><td>9000000</td><td>2.571000</td></tr><tr><td>Sub Total 8.B2</td><td colspan="3"></td><td>12728120</td><td>3.636000%</td></tr></tbody></table></div>9. Information in relation to the person subject to the notification obligation2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)<div><table><tbody><tr><td>Ultimate controlling person</td><td>Jefferies Financial Group Inc.</td></tr><tr><td>Name of controlled undertaking</td><td>Jefferies International Limited</td></tr><tr><td>% of voting rights if it equals or is higher than the notifiable threshold</td><td>1.029000</td></tr><tr><td>% of voting rights through financial instruments if it equals or is higher than the notifiable threshold</td><td>5.413000</td></tr><tr><td>Total of both if it equals or is higher than the notifiable threshold</td><td>6.442000%</td></tr></tbody></table></div>10. In case of proxy votingName of the proxy holderThe number and % of voting rights heldThe date until which the voting rights will be held11. Additional Information12. Date of Completion15-Jan-202613. Place Of CompletionLondon, United KingdomThis information is provided by RNS, the news service of the London Stock Exchange. RNS is approved by the Financial Conduct Authority to act as a Primary Information Provider in the United Kingdom. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@lseg.com or visit www.rns.com.RNS may use your IP address to confirm compliance with the terms and conditions, to analyse how you engage with the information contained in this communication, and to share such analysis on an anonymised basis with others as part of our commercial services. For further information about how RNS and the London Stock Exchange use the personal data you provide us, please see our Privacy Policy. END HOLGPUPCGUPQGAA</div></div>

Life Science REIT PLC announced that Jefferies Financial Group Inc. has crossed a significant threshold in voting rights. As of January 14, 2026, Jefferies holds 1.03% of voting rights attached to shares and 5.41% through financial instruments, totaling 6.44%. The notification was made on January 15, 2026, and the information is provided by RNS, the news service of the London Stock Exchange.

REG - Life Science REIT - Holding(s) in Company