<p>March 26 (Reuters) - Wall Street’s main indexes opened lower open on Thursday following gains in the previous session, as caution prevailed about developments in the Middle East while weighing the prospects for de-escalation in the conflict.</p>
<p>The Dow Jones Industrial Average  (.DJI)  fell 84.8 points, or 0.18%, at the open to 46,344.64. The S&amp;P 500  (.SPX)  fell 36.0 points, or 0.55%, to 6,555.86​, while the Nasdaq Composite (.IXIC)  dropped 236.7 points, or 1.08%, to 21,693.175.</p>

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- Wall Street's main indexes opened lower on March 26, following gains from the previous session.  
- The Dow Jones Industrial Average decreased by 84.8 points, or 0.18%, while the S&P 500 and Nasdaq Composite fell 36.0 points and 236.7 points, respectively.  
- Caution regarding developments in the Middle East influenced the market as investors considered the prospects for de-escalation in the conflict.

Reuters

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US STOCKS SNAPSHOT-Wall St opens lower as Mideast de-escalation uncertainty weighs