<div id="readability-page-1"><div><p><span>Barnes Alane P Officer of BioCryst Pharmaceuticals Inc [BCRX] filed a Form 4 on December 3, 2025 with the Securities and Exchange Commission disclosing the following changes in ownership:</span></p><div><table><tbody><tr><th><span>Date</span></th><th><span>Transaction</span></th><th><span>Shares</span></th><th><span>Price</span></th><th><span>Value</span></th></tr><tr><td><span>12/1/25</span></td><td><span>Planned Exercise(1)(2)</span></td><td><span>91,004</span></td><td><span>$3.22</span></td><td><span>$293,033</span></td></tr><tr><td><span>12/1/25-12/3/25</span></td><td><span>Sale</span></td><td><span>161,680</span></td><td><span>$7.21</span></td><td><span>$1,164,953</span></td></tr></tbody></table></div><p><span>Ending Holdings: 345,476 - Direct</span></p><div><table><tbody><tr><td><span>(1)</span></td><td><span>Exercised 5.7 months before expiration date.</span></td></tr><tr><td><span>(2)</span></td><td><span>Executed pursuant to a prearranged trading plan (10b5-1).</span></td></tr></tbody></table></div><p><span>For a free trial, or to learn more about our insider trading analysis and data services, please visit http://www.washingtonservice.com or contact us at (301) 913-5100 or send an email to info@washingtonservice.com.</span></p><p><span>Founded in 1970, The Washington Service provides securities professionals with financial, economic and public policy research and data.</span></p><span> </span></div></div>

BCRX

<p>Officer Alane P. Barnes of BioCryst Pharmaceuticals Inc. filed a Form 4 with the SEC, disclosing the sale of 161,680 shares for $1.2 million between December 1-3, 2025. The transaction was part of a prearranged trading plan (10b5-1). Barnes also exercised options for 91,004 shares at $3.22 each, totaling $293,033. Ending holdings are 345,476 shares directly.</p>

Officer Barnes Sells 161,680 ($1.2M) Of BioCryst Pharmaceuticals Inc [BCRX]