<div id="readability-page-1"><div><p><span>Wender Joseph H Director of Ionis Pharmaceuticals Inc [IONS] filed a Form 4 on December 3, 2025 with the Securities and Exchange Commission disclosing the following changes in ownership:</span></p><div><table><tbody><tr><td><span>Date</span></td><td><span>12/1/25</span></td></tr><tr><td><span>Transaction</span></td><td><span>Planned Sale(1)</span></td></tr><tr><td><span>Shares</span></td><td><span>28,000</span></td></tr><tr><td><span>Price</span></td><td><span>$80.82</span></td></tr><tr><td><span>Value</span></td><td><span>$2,262,848</span></td></tr></tbody></table></div><p><span>Ending Holdings: 52,035 (16,000 - Direct, 36,035 - Indirect)</span></p><ul><li><span>(1)</span></li><li><span>Executed pursuant to a prearranged trading plan (10b5-1).</span></li></ul><p><span>For a free trial, or to learn more about our insider trading analysis and data services, please visit http://www.washingtonservice.com or contact us at (301) 913-5100 or send an email to info@washingtonservice.com.</span></p><p><span>Founded in 1970, The Washington Service provides securities professionals with financial, economic and public policy research and data.</span></p><span> </span></div></div>

IONS

<p>Wender Joseph H, Director of Ionis Pharmaceuticals Inc, sold 28,000 shares worth $2.3 million on December 1, 2025, as disclosed in a Form 4 filing with the SEC. The sale was executed under a prearranged trading plan (10b5-1). After the sale, Wender holds 52,035 shares.</p>

Dir Wender Sells 28,000 ($2.3M) Of Ionis Pharmaceuticals Inc [IONS]