<div id="readability-page-1"><div><ul> <li>Protagonist Therapeutics and Takeda recently reported 52-week data from the pivotal Phase 3 VERIFY trial of rusfertide in polycythemia vera, showing durable control of hematocrit and reduced need for phlebotomy with a safety profile consistent with earlier findings.</li> <li>The program’s Breakthrough, Orphan Drug and Fast Track designations, combined with sustained response in a majority of continuously treated patients, highlight rusfertide’s potential to change care for phlebotomy-dependent PV patients.</li> <li>We’ll now look at how these durable Phase 3 rusfertide results may influence Protagonist Therapeutics’ investment narrative and long-term positioning.</li> </ul><p>This technology could replace computers: discover 28 stocks that are working to make quantum computing a reality.</p><h2>What Is Protagonist Therapeutics' Investment Narrative?</h2><p>To own Protagonist Therapeutics, you really have to believe in rusfertide as a meaningful new option for phlebotomy‑dependent polycythemia vera and in the company’s broader peptide platform, including its partnered psoriasis program with J&amp;J. The new 52‑week VERIFY data readout at ASH reinforces the durability and safety story that underpinned the earlier topline Phase 3 success, which matters because regulatory milestones for rusfertide now look like the key short‑term catalyst. With the share price already strong and the stock trading on a rich earnings multiple, incremental datapoints like these may not shift valuation overnight, but they can influence how investors handicap approval odds, launch potential and partnering economics. At the same time, ongoing operating losses and reliance on external partners keep funding and execution risk firmly in focus.</p><p> However, one risk in particular could challenge the bullish case more than many expect.  Despite retreating, Protagonist Therapeutics' shares might still be trading 24% above their fair value. Discover the potential downside here.</p><h2>Exploring Other Perspectives</h2><figure><img height="476" src="https://imageproxy.pbkrs.com/https://images.simplywall.st/company/fc7d3f36-7789-4a40-8892-bf2ab67f8e26/chart/community-fair-value?x-oss-process=image/auto-orient,1/interlace,1/resize,w_1440,h_1440/quality,q_95/format,jpg" width="746" original-src="https://imageproxy.pbkrs.com/https://images.simplywall.st/company/fc7d3f36-7789-4a40-8892-bf2ab67f8e26/chart/community-fair-value"/><figcaption>PTGX Community Fair Values as at Dec 2025</figcaption></figure> <p>Two fair value estimates from the Simply Wall St Community span roughly US$91 to US$117 per share, underscoring how differently private investors are thinking about upside. Set that against the rich earnings multiple and dependence on successful rusfertide execution, and it becomes clear why many readers may want to compare several viewpoints before deciding how Protagonist could fit into a portfolio.</p><p>Explore 2 other fair value estimates on Protagonist Therapeutics - why the stock might be worth as much as 31% more than the current price!</p><h2>Build Your Own Protagonist Therapeutics Narrative</h2><p>Disagree with this assessment? Create your own narrative in under 3 minutes - extraordinary investment returns rarely come from following the herd.</p><ul><li>A great starting point for your Protagonist Therapeutics research is our analysis highlighting 2 key rewards and 1 important warning sign that could impact your investment decision.</li><li>Our free Protagonist Therapeutics research report provides a comprehensive fundamental analysis summarized in a single visual - the Snowflake - making it easy to evaluate Protagonist Therapeutics' overall financial health at a glance.</li></ul><h2>Ready To Venture Into Other Investment Styles?</h2><p>These stocks are moving-our analysis flagged them today. Act fast before the price catches up:</p><ul><li>These 13 companies survived and thrived after COVID and have the right ingredients to survive Trump's tariffs. Discover why before your portfolio feels the trade war pinch.</li><li>Trump has pledged to &#34;unleash&#34; American oil and gas and these 22 US stocks have developments that are poised to benefit.</li><li>Uncover the next big thing with financially sound penny stocks that balance risk and reward.</li></ul> <p><em> This article by Simply Wall St is general in nature. <strong>We provide commentary based on historical data     and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice.</strong> It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your     financial situation. We aim to bring you long-term focused analysis driven by fundamental data.     Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material.     Simply Wall St has no position in any stocks mentioned.</em></p></div></div>

PTGX

<p>Protagonist Therapeutics' Phase 3 VERIFY trial data for rusfertide shows durable control in polycythemia vera, influencing its investment narrative. Despite strong share prices, the data may affect approval odds and partnering economics. Risks include operating losses and reliance on partners. Fair value estimates vary, highlighting differing investor perspectives. The article encourages creating personal investment narratives and provides fundamental analysis, but is not financial advice.</p>

Is Rusfertide’s Phase 3 VERIFY Durability Data Altering The Investment Case For Protagonist Therapeutics (PTGX)?