Autolus Therapeutics Reports Positive Phase 1 CARLYSLE Trial Data for Obe-cel in Severe Refractory Lupus

Reuters
2025.12.08 21:05
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Autolus Therapeutics announced positive preliminary results from its Phase 1 CARLYSLE trial for obe-cel in severe refractory lupus. The trial showed deep B-cell depletion and durable responses, with no severe safety issues reported. Following these results, Autolus has initiated the LUMINA Phase 2 trial for lupus nephritis. The findings were presented at the 2025 ASH Annual Meeting.